5zja A 2.6 BS01 FAD A 1 I6 G7 A8 G9 V10 I11 A36 D37 R38 T44 T45 A48 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 V10 I11 A36 D37 R38 T44 T45 A48 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 30265959 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja A 2.6 BS02 9E9 A 1 Y224 Y228 R283 Y224 Y228 R283 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 IC50=720nM P14920 30265959 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja B 2.6 BS01 FAD B 1 G7 G9 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 G7 G9 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 30265959 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja B 2.6 BS02 9E9 B 1 Y224 Y228 R283 Y224 Y228 R283 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 IC50=720nM P14920 30265959 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja C 2.6 BS01 FAD C 1 I6 G7 A8 G9 I11 A36 D37 R38 T43 T44 T45 A48 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 I11 A36 D37 R38 T43 T44 T45 A48 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 30265959 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja C 2.6 BS02 9E9 C 1 L51 Q53 Y224 Y228 R283 L51 Q53 Y224 Y228 R283 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 IC50=720nM P14920 30265959 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja D 2.6 BS01 FAD D 1 I6 G7 A8 G9 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 30265959 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 5zja D 2.6 BS02 9E9 D 1 Q53 Y224 Y228 R283 Q53 Y224 Y228 R283 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 IC50=720nM P14920 30265959 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS