5y80 A 2.5 BS01 IRE A 1 L46 K69 C126 G128 Q129 L180 L23 K46 C103 G105 Q106 L154 D173 K175 N178 D191 T223 D147 K149 N152 D165 T197 2.7.11.1 0004672,0005524,0006468 Kd=1.62nM -logKd/Ki=8.79, Kd=1.62nM O14976 30214852 401 SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELL 5y80 A 2.5 BS02 IRE A 2 A81 R172 G193 S194 H200 V214 I218 N221 Q244 A58 R146 G167 S168 H174 V188 I192 N195 Q218 D173 K175 N178 D191 T223 D147 K149 N152 D165 T197 2.7.11.1 0004672,0005524,0006468 Kd=1.62nM -logKd/Ki=8.79, Kd=1.62nM O14976 30214852 402 SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELL