5x6z A 2.1 BS01 GTP A 1 Q616 P622 K627 Y645 R648 S702 G703 H704 W722 D746 W758 H759 Q599 P605 K610 Y628 R631 S685 G686 H687 W705 D729 W741 H742 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 901 NPDYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVINEMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNWRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z A 2.1 BS02 GDP A 1 D50 M53 E134 V137 D48 M51 E132 V135 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 902 NPDYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVINEMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNWRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z B 2.1 BS01 GTP B 1 Q616 Y645 R648 S702 G703 H704 W722 D746 K748 W758 H759 Q591 Y620 R623 S677 G678 H679 W697 D721 K723 W733 H734 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 901 DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z B 2.1 BS02 GDP B 1 D50 M53 S54 E134 V137 D46 M49 S50 E130 V133 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 902 DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z C 2.1 BS01 GTP C 1 Q616 K627 Y645 R648 S702 G703 H704 W722 N747 W758 H759 Q592 K603 Y621 R624 S678 G679 H680 W698 N723 W734 H735 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 901 DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z C 2.1 BS02 GDP C 1 D50 M53 E134 V137 D46 M49 E130 V133 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 902 DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z D 2.1 BS01 GTP D 1 Y645 R648 H704 W722 M726 N747 K748 W758 H759 Y635 R638 H694 W712 M716 N737 K738 W748 H749 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 901 MSNPDYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIYVMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNPTGRRWRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x6z D 2.1 BS02 GDP D 1 D50 E134 V137 D50 E134 V137 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 902 MSNPDYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIYVMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNPTGRRWRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI