5x67 A 2.13 BS01 UMP A 1 R50 C195 H196 Q214 R215 S216 D218 N226 H256 Y258 R23 C168 H169 Q187 R188 S189 D191 N199 H229 Y231 E87 W109 Y135 C195 R215 D218 E60 W82 Y108 C168 R188 D191 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Kd=1.19uM P04818 28634233 401 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x67 A 2.13 BS02 7Z9 A 1 I108 W109 D218 L221 G222 F225 M311 A312 I81 W82 D191 L194 G195 F198 M284 A285 E87 W109 Y135 C195 R215 D218 E60 W82 Y108 C168 R188 D191 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=15nM P04818 28634233 402 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x67 A 2.13 BS03 UMP B 1 R175 R176 R148 R149 E87 W109 Y135 C195 R215 D218 E60 W82 Y108 C168 R188 D191 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Kd=1.19uM P04818 28634233 401 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x67 B 2.13 BS01 UMP A 1 R175 R176 R150 R151 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Kd=1.19uM P04818 28634233 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x67 B 2.13 BS02 UMP B 1 R50 C195 Q214 R215 S216 D218 N226 H256 Y258 R25 C170 Q189 R190 S191 D193 N201 H231 Y233 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Kd=1.19uM P04818 28634233 401 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x67 B 2.13 BS03 7Z9 B 1 I108 W109 D218 L221 G222 F225 M311 A312 I83 W84 D193 L196 G197 F200 M286 A287 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 Ki=15nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV