5wzr A 2.79 BS01 ZN A 1 C407 C445 H450 C407 C445 H450 3.2.1.- 0016798,0033926,0046872 G5ELM1 28546425 701 MMQFTMSGTMLRFDETTLRFSFSRDGATWSGCDGIEPQLTREDRSFSFAGAATVTHERIETGTGVGVRSVFAGFAGADYAFETYIWIERSSGDVLCEWVPLRECGAEPRIDRVLWPAPLSFDRADAHDVTLITHEQGVMIPNSWPTEVGTDAVSFGGRFETAGGYMPWFAQLRSDGHAYIAICETPWNAGYDIDHPAGGPYTHVGMWFEPSLGRMDYRRVVRYRLLDHADHTAICKTYRAYVNERGRLRTLAEKAARNPSVRDLLGRSWVHVGIKTNVQPDSSFYDPAQPGKNDSLVTFAQRERQMRTLHEMGAGRLYLHLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQGDLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNFSEIATHGIVLDCAYLDVFTCNEGDECSHPEHRMTRRECYERRAECFEYLLAHGILTSSEEVSDWAVPSLVFCHYAPYDFQMRSPDAPRHGIPVPLYNLVYHDCVIQPWMMDRVAGGDDYMLYALLNGGAPYLIRDAAYAGMDGDMNAALRTENDIERCAVVAGLHRRVGMQELVRHDLVGGDPLVQRSVFADGTAVTCDFHAQTYEVAANG 5wzr A 2.79 BS02 DJN A 1 Y329 D330 D371 W398 D435 V436 E478 H492 D561 Y329 D330 D371 W398 D435 V436 E478 H492 D561 3.2.1.- 0016798,0033926,0046872 -logKd/Ki=7.29, Ki=51nM G5ELM1 28546425 702 MMQFTMSGTMLRFDETTLRFSFSRDGATWSGCDGIEPQLTREDRSFSFAGAATVTHERIETGTGVGVRSVFAGFAGADYAFETYIWIERSSGDVLCEWVPLRECGAEPRIDRVLWPAPLSFDRADAHDVTLITHEQGVMIPNSWPTEVGTDAVSFGGRFETAGGYMPWFAQLRSDGHAYIAICETPWNAGYDIDHPAGGPYTHVGMWFEPSLGRMDYRRVVRYRLLDHADHTAICKTYRAYVNERGRLRTLAEKAARNPSVRDLLGRSWVHVGIKTNVQPDSSFYDPAQPGKNDSLVTFAQRERQMRTLHEMGAGRLYLHLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQGDLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNFSEIATHGIVLDCAYLDVFTCNEGDECSHPEHRMTRRECYERRAECFEYLLAHGILTSSEEVSDWAVPSLVFCHYAPYDFQMRSPDAPRHGIPVPLYNLVYHDCVIQPWMMDRVAGGDDYMLYALLNGGAPYLIRDAAYAGMDGDMNAALRTENDIERCAVVAGLHRRVGMQELVRHDLVGGDPLVQRSVFADGTAVTCDFHAQTYEVAANG 5wzr A 2.79 BS03 CA A 1 H271 H320 D322 H366 H271 H320 D322 H366 3.2.1.- 0016798,0033926,0046872 G5ELM1 28546425 703 MMQFTMSGTMLRFDETTLRFSFSRDGATWSGCDGIEPQLTREDRSFSFAGAATVTHERIETGTGVGVRSVFAGFAGADYAFETYIWIERSSGDVLCEWVPLRECGAEPRIDRVLWPAPLSFDRADAHDVTLITHEQGVMIPNSWPTEVGTDAVSFGGRFETAGGYMPWFAQLRSDGHAYIAICETPWNAGYDIDHPAGGPYTHVGMWFEPSLGRMDYRRVVRYRLLDHADHTAICKTYRAYVNERGRLRTLAEKAARNPSVRDLLGRSWVHVGIKTNVQPDSSFYDPAQPGKNDSLVTFAQRERQMRTLHEMGAGRLYLHLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQGDLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNFSEIATHGIVLDCAYLDVFTCNEGDECSHPEHRMTRRECYERRAECFEYLLAHGILTSSEEVSDWAVPSLVFCHYAPYDFQMRSPDAPRHGIPVPLYNLVYHDCVIQPWMMDRVAGGDDYMLYALLNGGAPYLIRDAAYAGMDGDMNAALRTENDIERCAVVAGLHRRVGMQELVRHDLVGGDPLVQRSVFADGTAVTCDFHAQTYEVAANG 5wzr B 2.79 BS01 ZN B 1 C407 C445 H450 C407 C445 H450 3.2.1.- 0016798,0033926,0046872 G5ELM1 28546425 701 MMQFTMSGTMLRFDETTLRFSFSRDGATWSGCDGIEPQLTREDRSFSFAGAATVTHERIETGTGVGVRSVFAGFAGADYAFETYIWIERSSGDVLCEWVPLRECGAEPRIDRVLWPAPLSFDRADAHDVTLITHEQGVMIPNSWPTEVGTDAVSFGGRFETAGGYMPWFAQLRSDGHAYIAICETPWNAGYDIDHPAGGPYTHVGMWFEPSLGRMDYRRVVRYRLLDHADHTAICKTYRAYVNERGRLRTLAEKAARNPSVRDLLGRSWVHVGIKTNVQPDSSFYDPAQPGKNDSLVTFAQRERQMRTLHEMGAGRLYLHLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQGDLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNFSEIATHGIVLDCAYLDVFTCNEGDECSHPEHRMTRRECYERRAECFEYLLAHGILTSSEEVSDWAVPSLVFCHYAPYDFQMRSPDAPRHGIPVPLYNLVYHDCVIQPWMMDRVAGGDDYMLYALLNGGAPYLIRDAAYAGMDGDMNAALRARTENDIERCAVVAGLHRRVGMQELVRHDLVGGDPLVQRSVFADGTAVTCDFHAQTYEVAA 5wzr B 2.79 BS02 DJN B 1 Y329 D330 D371 W398 Y433 D435 V436 E478 D561 Y329 D330 D371 W398 Y433 D435 V436 E478 D561 3.2.1.- 0016798,0033926,0046872 G5ELM1 28546425 702 MMQFTMSGTMLRFDETTLRFSFSRDGATWSGCDGIEPQLTREDRSFSFAGAATVTHERIETGTGVGVRSVFAGFAGADYAFETYIWIERSSGDVLCEWVPLRECGAEPRIDRVLWPAPLSFDRADAHDVTLITHEQGVMIPNSWPTEVGTDAVSFGGRFETAGGYMPWFAQLRSDGHAYIAICETPWNAGYDIDHPAGGPYTHVGMWFEPSLGRMDYRRVVRYRLLDHADHTAICKTYRAYVNERGRLRTLAEKAARNPSVRDLLGRSWVHVGIKTNVQPDSSFYDPAQPGKNDSLVTFAQRERQMRTLHEMGAGRLYLHLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQGDLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNFSEIATHGIVLDCAYLDVFTCNEGDECSHPEHRMTRRECYERRAECFEYLLAHGILTSSEEVSDWAVPSLVFCHYAPYDFQMRSPDAPRHGIPVPLYNLVYHDCVIQPWMMDRVAGGDDYMLYALLNGGAPYLIRDAAYAGMDGDMNAALRARTENDIERCAVVAGLHRRVGMQELVRHDLVGGDPLVQRSVFADGTAVTCDFHAQTYEVAA 5wzr B 2.79 BS03 CA B 1 H271 H320 D322 H366 H271 H320 D322 H366 3.2.1.- 0016798,0033926,0046872 G5ELM1 28546425 703 MMQFTMSGTMLRFDETTLRFSFSRDGATWSGCDGIEPQLTREDRSFSFAGAATVTHERIETGTGVGVRSVFAGFAGADYAFETYIWIERSSGDVLCEWVPLRECGAEPRIDRVLWPAPLSFDRADAHDVTLITHEQGVMIPNSWPTEVGTDAVSFGGRFETAGGYMPWFAQLRSDGHAYIAICETPWNAGYDIDHPAGGPYTHVGMWFEPSLGRMDYRRVVRYRLLDHADHTAICKTYRAYVNERGRLRTLAEKAARNPSVRDLLGRSWVHVGIKTNVQPDSSFYDPAQPGKNDSLVTFAQRERQMRTLHEMGAGRLYLHLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQGDLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNFSEIATHGIVLDCAYLDVFTCNEGDECSHPEHRMTRRECYERRAECFEYLLAHGILTSSEEVSDWAVPSLVFCHYAPYDFQMRSPDAPRHGIPVPLYNLVYHDCVIQPWMMDRVAGGDDYMLYALLNGGAPYLIRDAAYAGMDGDMNAALRARTENDIERCAVVAGLHRRVGMQELVRHDLVGGDPLVQRSVFADGTAVTCDFHAQTYEVAA