5wfd B 2.654 BS01 ZN B 1 C727 C748 C755 C760 C452 C471 C478 C483 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8001 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS02 ZN B 2 C736 C755 C763 C461 C478 C486 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8002 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS03 ZN B 3 C727 C729 C736 C746 C452 C454 C461 C469 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8003 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS04 ZN B 4 C685 H687 C691 C697 C410 H412 C416 C422 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8004 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS05 ZN B 5 C691 C709 C715 C720 C416 C434 C440 C445 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8005 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS06 ZN B 6 C699 C709 C713 C424 C434 C438 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8006 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS07 ZN B 7 C508 C511 C516 H518 C256 C259 C264 H266 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8007 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS08 ZN B 8 C570 C615 C625 C304 C345 C355 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8008 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS09 A9G B 1 I302 Y303 Y304 H307 G808 Y809 R843 Y878 I99 Y100 Y101 H104 G530 Y531 R565 Y590 ? 0006338,0042054 -logKd/Ki=4.58, IC50=26.2uM G0RYC6,G0SDW4 29904056 8009 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE