5wf7 B 2.5 BS01 ZN B 1 C727 C748 C755 C760 C432 C451 C458 C463 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8001 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS02 ZN B 2 C736 C755 C763 C784 C441 C458 C466 C487 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8002 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS03 ZN B 3 C727 C729 C736 C746 C432 C434 C441 C449 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8003 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS04 ZN B 4 C685 H687 C691 C697 C390 H392 C396 C402 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8004 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS05 ZN B 5 C691 C709 C715 C720 C396 C414 C420 C425 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8005 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS06 ZN B 6 C685 C699 C709 C713 C390 C404 C414 C418 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8006 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS07 ZN B 7 C508 C511 C516 H518 C240 C243 C248 H250 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8007 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS08 ZN B 8 C570 C574 C615 C625 C288 C292 C325 C335 ? 0006338,0042054 G0RYC6,G0SDW4 29904056 8008 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wf7 B 2.5 BS09 A9G B 1 Y303 R304 G808 Y809 R843 V853 Y878 Y103 R104 G511 Y512 R546 V552 Y577 ? 0006338,0042054 ic50=98.5uM -logKd/Ki=4.01, IC50=98.5uM G0RYC6,G0SDW4 29904056 8009 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE