5w8h A 1.8 BS01 9Y1 A 1 L108 N137 R168 H192 G193 Y238 T247 L108 N137 R168 H192 G193 Y238 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=23.4uM -logKd/Ki=4.63, IC50=23.4uM IC50=23400nM P00338 29120638 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5w8h A 1.8 BS02 9Y1 A 2 G26 D51 V52 A95 I115 I119 G26 D51 V52 A95 I115 I119 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=23.4uM -logKd/Ki=4.63, IC50=23.4uM IC50=23400nM P00338 29120638 502 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5w8h B 1.8 BS01 9Y1 B 1 S309 E310 R314 S309 E310 R314 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=23.4uM -logKd/Ki=4.63, IC50=23.4uM IC50=23400nM P00338 29120638 402 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5w8h C 1.8 BS01 9Y1 C 1 N137 R168 H192 G193 A237 N135 R166 H190 G191 A235 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=23.4uM IC50=23400nM P00338 29120638 501 ATLKDQLIYNLLKETPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5w8h C 1.8 BS02 9Y1 C 2 G26 D51 V52 A95 I115 F118 I119 G24 D49 V50 A93 I113 F116 I117 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=23.4uM IC50=23400nM P00338 29120638 502 ATLKDQLIYNLLKETPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5w8h C 1.8 BS03 9Y1 C 3 S104 R105 L106 D320 T321 G324 I325 S102 R103 L104 D318 T319 G322 I323 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=23.4uM IC50=23400nM P00338 29120638 503 ATLKDQLIYNLLKETPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF