5w4v A 2.65 BS01 9WA A 1 L287 C320 L324 M365 F377 F378 E379 F388 I400 L21 C54 L58 M99 F111 F112 E113 F122 I134 ? 0003677,0004879,0005634,0006355 -logKd/Ki=7.15, Kd=70nM Kd=5.0nM, IC50=89nM P51449 29079472 501 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSL 5w4v A 2.65 BS02 9WA B 1 M313 W317 M47 W51 ? 0003677,0004879,0005634,0006355 -logKd/Ki=7.15, Kd=70nM Kd=5.0nM, IC50=89nM P51449 29079472 501 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSL 5w4v B 2.65 BS01 9WA A 1 M313 W317 M47 W51 ? 0003677,0004879,0005634,0006355 -logKd/Ki=7.15, Kd=70nM Kd=5.0nM, IC50=89nM P51449 29079472 501 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSL 5w4v B 2.65 BS02 9WA B 1 C320 L324 M365 F377 F378 E379 F388 I400 C54 L58 M99 F111 F112 E113 F122 I134 ? 0003677,0004879,0005634,0006355 -logKd/Ki=7.15, Kd=70nM Kd=5.0nM, IC50=89nM P51449 29079472 501 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSL 5w4v C 2.65 BS01 9WA C 1 C320 L324 M365 V376 F377 F378 E379 F388 L396 I400 C51 L55 M96 V107 F108 F109 E110 F119 L127 I131 ? 0003677,0004879,0005634,0006355 Kd=5.0nM, IC50=89nM P51449 29079472 501 IEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSL 5w4v C 2.65 BS02 9WA F 1 M313 W314 M44 W45 ? 0003677,0004879,0005634,0006355 Kd=5.0nM, IC50=89nM P51449 29079472 501 IEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSL 5w4v D 2.65 BS01 9WA D 1 L287 C320 L324 M365 F377 F378 E379 F388 I400 L22 C55 L59 M100 F112 F113 E114 F123 I135 ? 0003677,0004879,0005634,0006355 Kd=5.0nM, IC50=89nM P51449 29079472 501 SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPP 5w4v E 2.65 BS01 9WA E 1 C320 L324 M365 F377 E379 F388 I400 C54 L58 M99 F111 E113 F122 I134 ? 0003677,0004879,0005634,0006355 Kd=5.0nM, IC50=89nM P51449 29079472 501 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKL 5w4v F 2.65 BS01 9WA F 1 C320 L324 L362 M365 F377 F378 E379 F388 I400 C54 L58 L96 M99 F111 F112 E113 F122 I134 ? 0003677,0004879,0005634,0006355 Kd=5.0nM, IC50=89nM P51449 29079472 501 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPP