5w19 A 2.1 BS01 9TD A 1 F37 T50 Q99 G100 R101 F132 D133 T134 N194 D223 R226 S263 K266 R414 F459 F36 T49 Q98 G99 R100 F131 D132 T133 N193 D222 R225 S262 K265 R413 F458 Y72 F132 D133 D223 A225 K266 I391 H458 Y71 F131 D132 D222 A224 K265 I390 H457 4.1.99.1 0006520,0006568,0006569,0009034,0009072,0016829,0016830 Ki~5uM -logKd/Ki=5.30, Kd~5uM P28796 30082510 502 AKRIVEPFRIKMVEKIRVPSREEREAALKEAGYNPFLLPSSAVYIDLLTDSGTNAMSDHQWAAMITGDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENILFPVLLKYKQKEGKAKNPVFISNFHFDTTAAHVELNGCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKYKNATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYGGLAGRDMAAMVQGLEEGTEEEYLHYRIGQVKYLGDRLREAGIPIQYPTGGHAVFVDCKKLVPQIPGDQFPAQAVINALYLESGVRAVEIGSFLLGRDPATGEQKHADMEFMRLTIARRVYTNDHMDYIADALIGLKEKFATLKGLEFEYEPPVLRHFTARLKPIE 5w19 B 2.1 BS01 9TD B 1 F37 T50 Q99 G100 R101 F132 D133 T134 N194 D223 R226 S263 K266 R414 F459 F36 T49 Q98 G99 R100 F131 D132 T133 N193 D222 R225 S262 K265 R413 F458 Y72 F132 D133 D223 A225 K266 I391 H458 Y71 F131 D132 D222 A224 K265 I390 H457 4.1.99.1 0006520,0006568,0006569,0009034,0009072,0016829,0016830 Ki~5uM -logKd/Ki=5.30, Kd~5uM P28796 30082510 501 AKRIVEPFRIKMVEKIRVPSREEREAALKEAGYNPFLLPSSAVYIDLLTDSGTNAMSDHQWAAMITGDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENILFPVLLKYKQKEGKAKNPVFISNFHFDTTAAHVELNGCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKYKNATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYGGLAGRDMAAMVQGLEEGTEEEYLHYRIGQVKYLGDRLREAGIPIQYPTGGHAVFVDCKKLVPQIPGDQFPAQAVINALYLESGVRAVEIGSFLLGRDPATGEQKHADMEFMRLTIARRVYTNDHMDYIADALIGLKEKFATLKGLEFEYEPPVLRHFTARLKPIE 5w19 C 2.1 BS01 9TD C 1 T50 Q99 G100 R101 F132 D133 T134 N194 D223 R226 S263 K266 R414 T49 Q98 G99 R100 F131 D132 T133 N193 D222 R225 S262 K265 R413 Y72 F132 D133 D223 A225 K266 I391 H458 Y71 F131 D132 D222 A224 K265 I390 H457 4.1.99.1 0006520,0006568,0006569,0009034,0009072,0016829,0016830 Ki~5uM P28796 30082510 503 AKRIVEPFRIKMVEKIRVPSREEREAALKEAGYNPFLLPSSAVYIDLLTDSGTNAMSDHQWAAMITGDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENILFPVLLKYKQKEGKAKNPVFISNFHFDTTAAHVELNGCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKYKNATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYGGLAGRDMAAMVQGLEEGTEEEYLHYRIGQVKYLGDRLREAGIPIQYPTGGHAVFVDCKKLVPQIPGDQFPAQAVINALYLESGVRAVEIGSFLLGRDPATGEQKHADMEFMRLTIARRVYTNDHMDYIADALIGLKEKFATLKGLEFEYEPPVLRHFTARLKPIE 5w19 D 2.1 BS01 9TD D 1 F37 T50 Q99 G100 R101 F132 D133 T134 N194 D223 R226 S263 K266 R414 F459 F36 T49 Q98 G99 R100 F131 D132 T133 N193 D222 R225 S262 K265 R413 F458 Y72 F132 D133 D223 A225 K266 I391 H458 Y71 F131 D132 D222 A224 K265 I390 H457 4.1.99.1 0006520,0006568,0006569,0009034,0009072,0016829,0016830 Ki~5uM P28796 30082510 501 AKRIVEPFRIKMVEKIRVPSREEREAALKEAGYNPFLLPSSAVYIDLLTDSGTNAMSDHQWAAMITGDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENILFPVLLKYKQKEGKAKNPVFISNFHFDTTAAHVELNGCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKYKNATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYGGLAGRDMAAMVQGLEEGTEEEYLHYRIGQVKYLGDRLREAGIPIQYPTGGHAVFVDCKKLVPQIPGDQFPAQAVINALYLESGVRAVEIGSFLLGRDPATGEQKHADMEFMRLTIARRVYTNDHMDYIADALIGLKEKFATLKGLEFEYEPPVLRHFTARLKPIE