5vsd A 1.85 BS01 SAM A 1 M1136 G1137 W1138 S1172 Y1173 F1198 N1200 H1201 Y1242 F1246 C1256 R1257 M131 G132 W133 S167 Y168 F189 N191 H192 Y233 F237 C247 R248 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3001 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd A 1.85 BS02 ZN A 1 C1062 C1075 C1105 C1109 C57 C70 C100 C104 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3002 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd A 1.85 BS03 ZN A 2 C1068 C1105 C1111 C1115 C63 C100 C106 C110 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3003 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd A 1.85 BS04 ZN A 3 C1062 C1064 C1068 C1073 C57 C59 C63 C68 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3004 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd A 1.85 BS05 ZN A 4 C1203 C1256 C1258 C1263 C194 C247 C249 C254 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3005 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd A 1.85 BS06 9HJ A 1 D1162 A1165 D1171 L1174 D1176 C1186 R1245 F1246 I1249 K1250 D157 A160 D166 L169 D171 C177 R236 F237 I240 K241 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Kd=57nM -logKd/Ki=7.24, Kd=57nM Kd=57nM, IC50=5.0nM Q9H9B1 28662962 3006 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd B 1.85 BS01 SAM B 1 M1136 G1137 W1138 S1172 Y1173 R1197 F1198 N1200 H1201 Y1242 F1246 C1256 R1257 M131 G132 W133 S167 Y168 R189 F190 N192 H193 Y234 F238 C248 R249 Y1155 Y1242 Y150 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3001 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd B 1.85 BS02 ZN B 1 C1062 C1075 C1105 C1109 C57 C70 C100 C104 Y1155 Y1242 Y150 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3002 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd B 1.85 BS03 ZN B 2 C1068 C1105 C1111 C1115 C63 C100 C106 C110 Y1155 Y1242 Y150 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3003 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd B 1.85 BS04 ZN B 3 C1062 C1064 C1068 C1073 C57 C59 C63 C68 Y1155 Y1242 Y150 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3004 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd B 1.85 BS05 ZN B 4 C1203 C1256 C1258 C1263 C195 C248 C250 C255 Y1155 Y1242 Y150 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28662962 3005 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5vsd B 1.85 BS06 9HJ B 1 A1165 D1171 L1174 D1176 R1245 F1246 I1249 K1250 A160 D166 L169 D171 R237 F238 I241 K242 Y1155 Y1242 Y150 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Kd=57nM Kd=57nM, IC50=5.0nM Q9H9B1 28662962 3006 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS