5vrw A 2.58 BS01 dna T 0 H34 K230 G231 T233 K234 R258 Y271 R283 L287 T292 I293 N294 E295 Y296 H26 K220 G221 T223 K224 R248 Y261 R273 L277 T282 I283 N284 E285 Y286 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 1 ~ 16 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS02 dna P 0 S104 G105 G107 P108 S109 A110 R254 D256 Y271 S96 G97 G99 P100 S101 A102 R244 D246 Y261 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 1 ~ 10 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS03 dna D 0 K35 Y39 G64 G66 K68 I69 K27 Y31 G56 G58 K60 I61 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 1 ~ 5 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS04 CA P 1 D190 D192 D256 D182 D184 D246 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 101 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS05 CA P 2 T101 V103 I106 T93 V95 I98 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 102 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS06 TTP P 1 S180 G189 D190 D192 Y271 F272 T273 G274 D276 N279 S172 G181 D182 D184 Y261 F262 T263 G264 D266 N269 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 IC50=1400nM P06746 28682600 103 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS07 CA D 1 K60 L62 V65 K52 L54 V57 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 101 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS08 CA A 1 D190 D192 D182 D184 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 401 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5vrw A 2.58 BS09 CA A 2 D314 D318 D304 D308 D190 D192 D256 D182 D184 D246 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 28682600 402 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE