5vl0 A 1.2 BS01 ZN A 1 C46 H67 C174 C46 H67 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 401 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 A 1.2 BS02 ZN A 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 402 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 A 1.2 BS03 NAI A 1 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 R369 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 403 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 A 1.2 BS04 BNF A 1 S48 H67 F93 C174 V294 I318 S48 H67 F93 C174 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.74uM P00327 28640600 404 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 B 1.2 BS01 ZN B 1 C46 H67 C174 C46 H67 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 401 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 B 1.2 BS02 ZN B 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 402 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 B 1.2 BS03 NAI B 1 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 R369 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 403 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 B 1.2 BS04 BNF B 1 S48 H67 F93 C174 V294 I318 S48 H67 F93 C174 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.74uM P00327 28640600 404 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 C 1.2 BS01 ZN C 1 C46 H67 C174 C46 H67 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 401 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 C 1.2 BS02 ZN C 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 402 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 C 1.2 BS03 NAI C 1 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 R369 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 403 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 C 1.2 BS04 BNF C 1 S48 H67 F93 C174 V294 I318 S48 H67 F93 C174 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.74uM P00327 28640600 404 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 D 1.2 BS01 ZN D 1 C46 H67 C174 C46 H67 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 401 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 D 1.2 BS02 ZN D 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 402 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 D 1.2 BS03 NAI D 1 C46 R47 S48 H51 C174 T178 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 C46 R47 S48 H51 C174 T178 G201 V203 D223 I224 I269 R271 V292 G293 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28640600 403 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5vl0 D 1.2 BS04 BNF D 1 S48 H67 F93 L116 C174 V294 I318 S48 H67 F93 L116 C174 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.74uM P00327 28640600 404 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF