5vdi A 3.1 BS01 7C6 A 1 I28 R29 F32 G160 Y161 I21 R22 F25 G153 Y154 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi A 3.1 BS02 GLY A 1 F159 T204 F152 T197 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi A 3.1 BS03 IVM A 1 S267 V280 A288 L291 S260 V273 A281 L284 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi A 3.1 BS04 ZN A 1 D194 H215 D187 H208 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 404 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi A 3.1 BS05 7C6 E 1 P10 Y78 D84 L85 P3 Y71 D77 L78 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi A 3.1 BS06 GLY E 1 F63 R65 S129 F56 R58 S122 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi A 3.1 BS07 IVM E 1 I225 I229 P230 I218 I222 P223 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi B 3.1 BS01 7C6 A 1 P10 L83 D84 L85 D86 P5 L78 D79 L80 D81 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 APMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 5vdi B 3.1 BS02 GLY A 1 F63 R65 S129 F58 R60 S124 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 APMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 5vdi B 3.1 BS03 IVM A 1 I225 I229 P230 I220 I224 P225 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 APMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 5vdi B 3.1 BS04 7C6 B 1 I28 R29 F32 G160 Y161 I23 R24 F27 G155 Y156 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 APMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 5vdi B 3.1 BS05 GLY B 1 F159 T204 F154 T199 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 APMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 5vdi B 3.1 BS06 IVM B 1 S267 S278 A288 L291 S262 S273 A283 L286 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 APMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 5vdi C 3.1 BS01 7C6 B 1 P10 L83 D84 L85 P3 L76 D77 L78 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi C 3.1 BS02 GLY B 1 F63 R65 S129 F56 R58 S122 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi C 3.1 BS03 IVM B 1 I225 I229 P230 L233 I218 I222 P223 L226 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi C 3.1 BS04 7C6 C 1 R27 I28 R29 F32 G160 Y161 R20 I21 R22 F25 G153 Y154 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi C 3.1 BS05 IVM C 1 S267 V280 L291 S260 V273 L284 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi C 3.1 BS06 ZN C 1 E192 D194 H215 E185 D187 H208 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 404 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi C 3.1 BS07 GLY D 1 F159 Y202 T204 F207 F152 Y195 T197 F200 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi D 3.1 BS01 7C6 C 1 P10 Y78 L83 D84 L85 P4 Y72 L77 D78 L79 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI 5vdi D 3.1 BS02 GLY C 1 F159 Y202 T204 F153 Y196 T198 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI 5vdi D 3.1 BS03 IVM C 1 I225 I229 P230 I219 I223 P224 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI 5vdi D 3.1 BS04 7C6 D 1 I28 R29 F32 G160 Y161 I22 R23 F26 G154 Y155 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI 5vdi D 3.1 BS05 GLY D 1 F63 R65 S129 F57 R59 S123 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI 5vdi D 3.1 BS06 IVM D 1 T264 S267 A288 L291 F295 T258 S261 A282 L285 F289 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI 5vdi E 3.1 BS01 GLY C 1 F63 R65 S129 F56 R58 S122 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 402 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi E 3.1 BS02 7C6 D 1 P10 Y78 D84 L85 P3 Y71 D77 L78 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi E 3.1 BS03 IVM D 1 I225 P230 I218 P223 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 O75311 28479061 403 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi E 3.1 BS04 7C6 E 1 R29 F32 G160 Y161 R22 F25 G153 Y154 ? 0004888,0005216,0005230,0005886,0006811,0016020,0016594,0022824,0034220 EC50=50nM, Kd=11nM O75311 28479061 401 MSPSDFLDKLMGRTSGYDARIRPNFKGPPVQVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 5vdi E 3.1 BS05 GLY E 1 F159 T204 F152 T197 ? 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