5uwn A 3.2 BS01 ZN A 1 H222 H226 H232 H114 H118 H124 H222 E223 H226 H232 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 RTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn A 3.2 BS02 ZN A 2 H172 D174 H187 H200 H64 D66 H79 H92 H222 E223 H226 H232 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 RTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn A 3.2 BS03 CA A 1 D179 G180 S182 L184 D202 E205 D71 G72 S74 L76 D94 E97 H222 E223 H226 H232 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 RTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn A 3.2 BS04 CA A 2 D162 N194 G196 D198 D54 N86 G88 D90 H222 E223 H226 H232 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 RTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn A 3.2 BS05 8O7 A 1 L184 L185 L218 H222 E223 F241 P242 I243 Y244 T245 T247 P255 L76 L77 L110 H114 E115 F133 P134 I135 Y136 T137 T139 P147 H222 E223 H226 H232 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=7.87, Ki=13.5nM Ki=14nM, IC50=8.3nM P45452 28653849 305 RTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn B 3.2 BS01 ZN B 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP 5uwn B 3.2 BS02 ZN B 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP 5uwn B 3.2 BS03 CA B 1 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP 5uwn B 3.2 BS04 CA B 2 D162 N194 G196 D198 D59 N91 G93 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP 5uwn B 3.2 BS05 8O7 B 1 L184 L185 A186 L218 H222 L239 F241 P242 I243 Y244 T245 T247 L81 L82 A83 L115 H119 L136 F138 P139 I140 Y141 T142 T144 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=14nM, IC50=8.3nM P45452 28653849 305 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP 5uwn C 3.2 BS01 ZN C 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn C 3.2 BS02 ZN C 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn C 3.2 BS03 CA C 1 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn C 3.2 BS04 CA C 2 D162 N194 G196 D198 D59 N91 G93 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn C 3.2 BS05 8O7 C 1 L218 V219 H222 L239 F241 P242 I243 Y244 T245 F252 L115 V116 H119 L136 F138 P139 I140 Y141 T142 F149 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=14nM, IC50=8.3nM P45452 28653849 305 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn D 3.2 BS01 ZN D 1 H222 H226 H232 H118 H122 H128 H222 E223 H226 H232 H118 E119 H122 H128 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 NVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn D 3.2 BS02 ZN D 2 H172 D174 H187 H200 H68 D70 H83 H96 H222 E223 H226 H232 H118 E119 H122 H128 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 NVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn D 3.2 BS03 CA D 1 D179 G180 S182 L184 D202 E205 D75 G76 S78 L80 D98 E101 H222 E223 H226 H232 H118 E119 H122 H128 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 NVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn D 3.2 BS04 CA D 2 D162 N194 G196 D198 D58 N90 G92 D94 H222 E223 H226 H232 H118 E119 H122 H128 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 NVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn D 3.2 BS05 8O7 D 1 L184 L185 A186 L218 H222 E223 L239 F241 P242 I243 Y244 T245 T247 F252 L80 L81 A82 L114 H118 E119 L135 F137 P138 I139 Y140 T141 T143 F148 H222 E223 H226 H232 H118 E119 H122 H128 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=14nM, IC50=8.3nM P45452 28653849 305 NVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn E 3.2 BS01 ZN E 1 H222 H226 H232 H120 H124 H130 H222 E223 H226 H232 H120 E121 H124 H130 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 MYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn E 3.2 BS02 ZN E 2 H172 D174 H187 H200 H70 D72 H85 H98 H222 E223 H226 H232 H120 E121 H124 H130 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 MYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn E 3.2 BS03 CA E 1 D179 G180 P181 S182 L184 D202 E205 D77 G78 P79 S80 L82 D100 E103 H222 E223 H226 H232 H120 E121 H124 H130 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 MYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn E 3.2 BS04 CA E 2 D162 N194 G196 D198 D60 N92 G94 D96 H222 E223 H226 H232 H120 E121 H124 H130 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 MYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5uwn E 3.2 BS05 8O7 E 1 M103 Y104 L184 L185 A186 H222 E223 A238 L239 F241 P242 I243 Y244 T245 T247 P255 M1 Y2 L82 L83 A84 H120 E121 A136 L137 F139 P140 I141 Y142 T143 T145 P153 H222 E223 H226 H232 H120 E121 H124 H130 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=14nM, IC50=8.3nM P45452 28653849 305 MYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG