5uwm A 1.62 BS01 peptide C 0 Y176 A186 H187 A188 F189 P190 H222 E223 H226 H232 Y66 A76 H77 A78 F79 P80 H112 E113 H116 H122 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 211 ~ 215 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm A 1.62 BS02 ZN A 1 H222 H226 H232 H112 H116 H122 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm A 1.62 BS03 ZN A 2 H172 D174 H187 H200 H62 D64 H77 H90 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm A 1.62 BS04 CA A 1 D179 G180 S182 L184 D202 E205 D69 G70 S72 L74 D92 E95 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm A 1.62 BS05 CA A 2 D128 D203 E205 D18 D93 E95 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm A 1.62 BS06 CA A 3 D162 N194 Y195 G196 D198 D52 N84 Y85 G86 D88 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 305 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm A 1.62 BS07 8OA A 1 G183 L184 L185 H222 E223 L239 F241 P242 I243 Y244 T245 T247 F252 P255 G73 L74 L75 H112 E113 L129 F131 P132 I133 Y134 T135 T137 F139 P142 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=356nM -logKd/Ki=6.45, IC50=356nM IC50=356nM P45452 28653849 306 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGP 5uwm B 1.62 BS01 peptide D 0 Y176 A186 H187 A188 F189 H222 E223 H226 H232 Y66 A76 H77 A78 F79 H112 E113 H116 H122 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 212 ~ 215 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS02 8OA A 1 F241 P242 F131 P132 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=356nM IC50=356nM P45452 28653849 306 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS03 ZN B 1 H222 H226 H232 H112 H116 H122 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 301 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS04 ZN B 2 H172 D174 H187 H200 H62 D64 H77 H90 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 302 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS05 CA B 1 D179 G180 S182 L184 D202 E205 D69 G70 S72 L74 D92 E95 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 303 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS06 CA B 2 D128 D203 E205 D18 D93 E95 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 304 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS07 CA B 3 D162 N194 G196 D198 D52 N84 G86 D88 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 28653849 305 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG 5uwm B 1.62 BS08 8OA B 1 L184 L185 H222 E223 L239 F241 P242 I243 Y244 T245 L74 L75 H112 E113 L129 F131 P132 I133 Y134 T135 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=356nM IC50=356nM P45452 28653849 306 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYFMLPDDDVQGIQSLYGPG