5up3 A 2.95 BS01 8GS A 1 L686 G687 K709 M754 E755 Q756 V757 G760 L810 S821 D822 L17 G18 K40 M80 E81 Q82 V83 G86 L136 S147 D148 D803 K805 D807 N808 D822 T842 D129 K131 D133 N134 D148 T160 2.7.11.25 0004672,0005524,0006468 -logKd/Ki=7.90, IC50=12.59nM IC50=13nM Q99683 28337323 1000 LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLTFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKV 5up3 B 2.95 BS01 8GS B 1 L686 A707 K709 M754 E755 Q756 V757 G760 L810 S821 D822 L16 A37 K39 M78 E79 Q80 V81 G84 L134 S145 D146 D803 K805 D807 N808 D822 T842 D127 K129 D131 N132 D146 T155 2.7.11.25 0004672,0005524,0006468 IC50=13nM Q99683 28337323 1000 LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLGTLQYMAPEIIDGYGKAADIWSLGCTIIEMATGKPPFYQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK