5uis A 2.5 BS01 8C1 A 1 E194 V200 A211 Y262 Y264 M265 A315 N316 L318 E30 V34 A45 Y85 Y87 M88 A138 N139 L141 D311 K313 A315 N316 D329 T351 D134 K136 A138 N139 D152 T166 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=146nM -logKd/Ki=6.84, IC50=146nM IC50=146nM Q9NWZ3 28498658 800 FHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNNTTVAVKKLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARAMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 5uis B 2.5 BS01 8C1 B 1 E194 V200 A211 Y262 Y264 M265 G268 A315 L318 E30 V36 A47 Y88 Y90 M91 G94 A141 L144 D311 K313 A315 N316 D329 T351 D137 K139 A141 N142 D155 T170 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=146nM IC50=146nM Q9NWZ3 28498658 801 FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAEELKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 5uis C 2.5 BS01 8C1 C 1 E194 V200 A211 Y262 Y264 M265 G268 A315 L318 E33 V37 A48 Y86 Y88 M89 G92 A139 L142 D311 K313 A315 N316 D329 T351 D135 K137 A139 N140 D153 T167 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=146nM IC50=146nM Q9NWZ3 28498658 501 DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNNTTVAVKKLAELKQQFDQEIKVMAKCQHENLVELLGFSLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARAMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 5uis D 2.5 BS01 8C1 D 1 E194 V200 A211 Y262 Y264 M265 G268 A315 L318 E22 V26 A34 Y65 Y67 M68 G71 A118 L121 D311 K313 A315 N316 D329 T351 D114 K116 A118 N119 D132 T146 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=146nM IC50=146nM Q9NWZ3 28498658 501 FHSFSFYELKNVTNDERPKMGEGGVVYKGYVTVAVKKLFDQEIKVMAKCQHENLVELLGFSCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARAMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT