5ugh A 2.062 BS01 8AJ A 1 L315 S331 I332 F333 E342 L289 S305 I306 F307 E316 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H18 D20 K21 E46 E59 K157 F226 D232 A233 R238 K239 K259 K263 D265 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 Kd=170nM -logKd/Ki=6.77, Kd=170nM P31153 28553945 401 FIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh A 2.062 BS02 8AJ C 1 F18 F20 Q190 G273 W274 F7 F9 Q166 G247 W248 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H18 D20 K21 E46 E59 K157 F226 D232 A233 R238 K239 K259 K263 D265 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 Kd=170nM -logKd/Ki=6.77, Kd=170nM P31153 28553945 401 FIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh B 2.062 BS01 8AJ B 1 L315 S331 I332 F333 E342 L285 S301 I302 F303 E312 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H19 D21 K22 E47 E60 K153 F222 D228 A229 R234 K235 K255 K259 D261 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 Kd=170nM P31153 28553945 401 AFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh B 2.062 BS02 8AJ B 2 F18 F20 Q190 W274 F8 F10 Q162 W244 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H19 D21 K22 E47 E60 K153 F222 D228 A229 R234 K235 K255 K259 D261 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 Kd=170nM P31153 28553945 402 AFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh C 2.062 BS01 8AJ A 1 G16 F18 F20 G273 W274 G3 F5 F7 G246 W247 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H16 D18 K19 E44 E57 K156 F225 D231 A232 R237 K238 K258 K262 D264 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 Kd=170nM -logKd/Ki=6.77, Kd=170nM P31153 28553945 401 EEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh C 2.062 BS02 8AJ C 1 L315 S331 I332 F333 E342 L288 S304 I305 F306 E315 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H16 D18 K19 E44 E57 K156 F225 D231 A232 R237 K238 K258 K262 D264 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 Kd=170nM -logKd/Ki=6.77, Kd=170nM P31153 28553945 401 EEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh D 2.062 BS01 8AJ B 1 E15 G16 F18 F20 Q190 G273 W274 E3 G4 F6 F8 Q163 G244 W245 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H17 D19 K20 E45 E58 K154 F223 D229 A230 R235 K236 K256 K260 D262 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 P31153 28553945 401 IEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 5ugh D 2.062 BS02 8AJ B 2 L315 S331 I332 F333 E342 L286 S302 I303 F304 E313 H29 D31 K32 E57 E70 K181 F250 D258 A259 R264 K265 K285 K289 D291 H17 D19 K20 E45 E58 K154 F223 D229 A230 R235 K236 K256 K260 D262 2.5.1.6 0004478,0005515,0005524,0005829,0006556,0006730,0016740,0034214,0036094,0042802,0046872,0048269,0051291,0061431,1904263,1990830 P31153 28553945 402 IEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY