5u4x A 1.88 BS01 SAH A 1 Y150 F151 Y154 Q160 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 E244 M269 S272 Y4 F5 Y8 Q14 M17 R23 G47 C48 I52 L53 E69 A70 K96 V97 E98 M123 S126 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Ki=400nM Q86X55 29719619 501 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5u4x A 1.88 BS02 7VM A 1 Y150 F153 Y154 M163 E258 M260 Y262 N266 E267 H415 Q447 K471 P473 F475 Y4 F7 Y8 M17 E112 M114 Y116 N120 E121 H269 Q301 K325 P327 F329 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 -logKd/Ki=8.15, Kd=7.1nM Q86X55 29719619 502 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5u4x B 1.88 BS01 SAH B 1 Y150 F151 Y154 Q160 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 E244 M269 S272 Y4 F5 Y8 Q14 M17 R23 G47 C48 I52 L53 E69 A70 K96 V97 E98 M123 S126 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Ki=400nM Q86X55 29719619 501 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFR 5u4x B 1.88 BS02 7VM B 1 Y150 F153 Y154 M163 E258 M260 Y262 N266 E267 H415 Q447 K471 P473 F475 Y4 F7 Y8 M17 E112 M114 Y116 N120 E121 H269 Q301 K325 P327 F329 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Q86X55 29719619 502 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFR 5u4x C 1.88 BS01 SAH C 1 Y150 F151 Y154 Q160 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 M269 S272 Y4 F5 Y8 Q14 M17 R23 G47 C48 I52 L53 E69 A70 K96 V97 M123 S126 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Ki=400nM Q86X55 29719619 501 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFR 5u4x C 1.88 BS02 7VM C 1 Y150 F153 Y154 M163 E258 M260 Y262 N266 E267 H415 Q447 K471 P473 F475 Y4 F7 Y8 M17 E112 M114 Y116 N120 E121 H269 Q301 K325 P327 F329 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Q86X55 29719619 502 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFR 5u4x D 1.88 BS01 SAH D 1 Y150 F151 Y154 Q160 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 E258 M269 S272 Y4 F5 Y8 Q14 M17 R23 G47 C48 I52 L53 E69 A70 K96 V97 E112 M123 S126 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Ki=400nM Q86X55 29719619 501 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5u4x D 1.88 BS02 7VM D 1 Y150 F153 Y154 M163 E258 M260 Y262 N266 E267 H415 Q447 K471 P473 F475 Y4 F7 Y8 M17 E112 M114 Y116 N120 E121 H269 Q301 K325 P327 F329 D166 E258 E267 H415 D20 E112 E121 H269 2.1.1.319 0016274,0018216 Q86X55 29719619 502 AVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY