5tuz A 1.95 BS01 SAM A 1 M1136 G1137 W1138 S1172 Y1173 R1197 F1198 N1200 H1201 Y1242 C1256 R1257 M131 G132 W133 S167 Y168 R190 F191 N193 H194 Y235 C249 R250 Y1155 Y1242 Y150 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3001 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz A 1.95 BS02 ZN A 1 C1062 C1075 C1105 C1109 C57 C70 C100 C104 Y1155 Y1242 Y150 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3002 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz A 1.95 BS03 ZN A 2 C1068 C1105 C1111 C1115 C63 C100 C106 C110 Y1155 Y1242 Y150 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3003 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz A 1.95 BS04 ZN A 3 C1062 C1064 C1068 C1073 C57 C59 C63 C68 Y1155 Y1242 Y150 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3004 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz A 1.95 BS05 ZN A 4 C1203 C1256 C1258 C1263 C196 C249 C251 C256 Y1155 Y1242 Y150 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3005 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz A 1.95 BS06 7L6 A 1 A1165 D1166 R1168 D1171 L1174 D1176 R1245 F1246 I1249 A160 D161 R163 D166 L169 D171 R238 F239 I242 Y1155 Y1242 Y150 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Kd=40nM -logKd/Ki=7.40, Kd=40nM IC50=13nM, Kd=40nM Q9H9B1 28135087 3006 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz B 1.95 BS01 SAM B 1 M1136 W1138 Y1173 R1197 F1198 N1200 H1201 Y1242 F1246 F1254 C1256 R1257 M131 W133 Y168 R188 F189 N191 H192 Y233 F237 F245 C247 R248 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3001 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz B 1.95 BS02 ZN B 1 C1062 C1075 C1105 C1109 C57 C70 C100 C104 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3002 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz B 1.95 BS03 ZN B 2 C1068 C1105 C1111 C1115 C63 C100 C106 C110 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3003 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz B 1.95 BS04 ZN B 3 C1062 C1064 C1068 C1073 C57 C59 C63 C68 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3004 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz B 1.95 BS05 ZN B 4 C1203 C1256 C1258 C1263 C194 C247 C249 C254 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q9H9B1 28135087 3005 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 5tuz B 1.95 BS06 7L6 B 1 D1162 A1165 D1166 D1171 L1174 D1176 R1245 F1246 I1249 K1250 D157 A160 D161 D166 L169 D171 R236 F237 I240 K241 Y1155 Y1242 Y150 Y233 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Kd=40nM IC50=13nM, Kd=40nM Q9H9B1 28135087 3006 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS