5tuy A 2.6 BS01 ZN A 1 C980 C1017 C1023 C1027 C60 C97 C103 C107 Y1067 Y1154 Y147 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1501 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS 5tuy A 2.6 BS02 ZN A 2 C974 C987 C1017 C1021 C54 C67 C97 C101 Y1067 Y1154 Y147 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1502 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS 5tuy A 2.6 BS03 ZN A 3 C974 C976 C980 C985 C54 C56 C60 C65 Y1067 Y1154 Y147 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1503 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS 5tuy A 2.6 BS04 ZN A 4 C1115 C1168 C1170 C1175 C195 C248 C250 C255 Y1067 Y1154 Y147 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1504 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS 5tuy A 2.6 BS05 SAM A 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169 M128 W130 S164 Y165 R189 F190 N192 H193 Y234 F246 C248 Q249 Y1067 Y1154 Y147 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1505 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS 5tuy A 2.6 BS06 7L6 A 1 D1074 A1077 D1078 R1080 D1083 L1086 D1088 R1157 F1158 D154 A157 D158 R160 D163 L166 D168 R237 F238 Y1067 Y1154 Y147 Y234 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 -logKd/Ki=6.35, Kd=445nM IC50=1.6nM, Kd=445nM Q96KQ7 28135087 1506 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS 5tuy B 2.6 BS01 ZN B 1 C980 C1017 C1023 C1027 C58 C95 C101 C105 Y1067 Y1154 Y145 Y229 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1501 CRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSK 5tuy B 2.6 BS02 ZN B 2 C974 C987 C1017 C1021 C52 C65 C95 C99 Y1067 Y1154 Y145 Y229 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1502 CRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSK 5tuy B 2.6 BS03 ZN B 3 C974 C976 C980 C985 C52 C54 C58 C63 Y1067 Y1154 Y145 Y229 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1503 CRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSK 5tuy B 2.6 BS04 ZN B 4 C1115 C1168 C1170 C1175 C190 C243 C245 C250 Y1067 Y1154 Y145 Y229 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1504 CRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSK 5tuy B 2.6 BS05 SAM B 1 M1048 G1049 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169 M126 G127 W128 S162 Y163 R184 F185 N187 H188 Y229 F241 C243 Q244 Y1067 Y1154 Y145 Y229 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 28135087 1505 CRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSK 5tuy B 2.6 BS06 7L6 B 1 A1077 D1078 D1083 L1086 D1088 F1158 I1161 K1162 A155 D156 D161 L164 D166 F233 I236 K237 Y1067 Y1154 Y145 Y229 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 IC50=1.6nM, Kd=445nM Q96KQ7 28135087 1506 CRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSK