5tqh A 2.2 BS01 7J2 A 1 R109 A111 R119 L120 W124 P127 I128 I130 M259 A282 Y285 M291 R107 A109 R117 L118 W122 P125 I126 I128 M254 A271 Y274 M280 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.02uM IC50=20nM O75874 28197303 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5tqh A 2.2 BS02 NDP A 1 T75 T77 N96 Q283 L288 H309 G310 T311 V312 T313 R314 H315 T327 N328 T73 T75 N94 Q272 L277 H298 G299 T300 V301 T302 R303 H304 T316 N317 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 O75874 28197303 503 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5tqh B 2.2 BS01 7J2 B 1 R109 A111 R119 L120 W124 I128 I130 W267 S278 V281 M291 R107 A109 R117 L118 W122 I126 I128 W262 S273 V276 M286 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.02uM IC50=20nM O75874 28197303 501 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5tqh B 2.2 BS02 NDP B 1 T75 T77 N96 Q283 L288 H309 G310 T311 V312 T313 R314 H315 N328 T73 T75 N94 Q278 L283 H304 G305 T306 V307 T308 R309 H310 N323 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 O75874 28197303 503 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5tqh C 2.2 BS01 7J2 C 1 R109 A111 R119 L120 W124 I128 I130 W267 S278 Y285 M291 R107 A109 R117 L118 W122 I126 I128 W261 S272 Y279 M285 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.02uM IC50=20nM O75874 28197303 501 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 5tqh C 2.2 BS02 NDP C 1 A74 T75 T77 R82 N96 L288 H309 G310 T311 V312 T313 R314 H315 T327 N328 A72 T73 T75 R80 N94 L282 H303 G304 T305 V306 T307 R308 H309 T321 N322 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 O75874 28197303 503 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 5tqh D 2.2 BS01 7J2 D 1 R109 A111 I113 R119 L120 W124 I128 I130 W267 A282 Y285 M291 R106 A108 I110 R116 L117 W121 I125 I127 W264 A272 Y275 M281 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.02uM IC50=20nM O75874 28197303 501 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5tqh D 2.2 BS02 NDP D 1 T75 T77 N96 L288 H309 G310 T311 V312 T313 R314 H315 N328 T72 T74 N93 L278 H299 G300 T301 V302 T303 R304 H305 N318 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 O75874 28197303 503 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA