5tf9 A 2.5 BS01 7AV A 1 L252 F265 E268 V281 F283 L299 D368 L369 G370 A372 L43 F56 E59 V72 F74 L87 D156 L157 G158 A160 D349 K351 D353 N354 D368 K375 T386 D137 K139 D141 N142 D156 K163 T165 2.7.11.1 0004672,0005524,0006468 Kd=4.4uM IC50=420nM Q9H4A3 27712055 501 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET 5tf9 A 2.5 BS02 ANP A 1 G228 G230 K233 A248 M304 K351 G19 G21 K24 A39 M92 K139 D349 K351 D353 N354 D368 K375 T386 D137 K139 D141 N142 D156 K163 T165 2.7.11.1 0004672,0005524,0006468 Q9H4A3 27712055 502 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET 5tf9 A 2.5 BS03 MN A 1 N354 D368 N142 D156 D349 K351 D353 N354 D368 K375 T386 D137 K139 D141 N142 D156 K163 T165 2.7.11.1 0004672,0005524,0006468 Q9H4A3 27712055 503 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET 5tf9 A 2.5 BS04 CA A 1 S423 C425 S202 C204 D349 K351 D353 N354 D368 K375 T386 D137 K139 D141 N142 D156 K163 T165 2.7.11.1 0004672,0005524,0006468 Q9H4A3 27712055 504 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET 5tf9 B 2.5 BS01 7AV B 1 F265 E268 V281 F283 L299 D368 L369 G370 A372 F60 E63 V76 F78 L94 D163 L164 G165 A167 D349 K351 D353 N354 D368 K375 T386 D144 K146 D148 N149 D163 K170 T172 2.7.11.1 0004672,0005524,0006468 Kd=4.4uM IC50=420nM Q9H4A3 27712055 501 ELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ 5tf9 B 2.5 BS02 ANP B 1 G228 R229 G230 K233 L303 M304 K351 G23 R24 G25 K28 L98 M99 K146 D349 K351 D353 N354 D368 K375 T386 D144 K146 D148 N149 D163 K170 T172 2.7.11.1 0004672,0005524,0006468 Q9H4A3 27712055 502 ELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ 5tf9 B 2.5 BS03 MN B 1 N354 D368 N149 D163 D349 K351 D353 N354 D368 K375 T386 D144 K146 D148 N149 D163 K170 T172 2.7.11.1 0004672,0005524,0006468 Q9H4A3 27712055 503 ELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKGTPEFMAPEMYAAAYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ