5tcc A 3.37 BS01 J56 A 1 L40 C41 H56 C57 R152 K195 G196 S198 S214 G215 S216 R217 L25 C26 H41 C42 R137 K180 G181 S183 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 -logKd/Ki=5.66, Kd=2.21uM IC50=77nM, Kd=2210nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc B 3.37 BS01 J56 B 1 L40 C41 K195 G196 S198 S214 G215 S216 R217 L25 C26 K180 G181 S183 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc C 3.37 BS01 J56 A 1 H148 A149 H133 A134 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc C 3.37 BS02 J56 C 1 L40 C41 H56 C57 K195 G196 S198 S214 G215 S216 R217 L25 C26 H41 C42 K180 G181 S183 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 301 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc C 3.37 BS03 J56 C 2 L137 H158 L160 P162 R191 L122 H143 L145 P147 R176 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 302 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc D 3.37 BS01 J56 D 1 L40 C41 H56 C57 R152 K195 G196 S198 S214 G215 S216 R217 L25 C26 H41 C42 R137 K180 G181 S183 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc D 3.37 BS02 J56 E 2 V66 A90 V51 A75 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 302 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc E 3.37 BS01 J56 E 1 L40 C41 H56 C57 K195 G196 S198 S214 G215 S216 R217 L25 C26 H41 C42 K180 G181 S183 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 301 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc E 3.37 BS02 J56 E 2 G18 L137 L160 P162 G3 L122 L145 P147 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 302 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc F 3.37 BS01 J56 F 1 L40 C41 H56 C57 R152 K195 G196 S198 S214 G215 S216 R217 L25 C26 H41 C42 R137 K180 G181 S183 S199 G200 S201 R202 H56 D104 K195 G196 D197 S198 G199 H41 D89 K180 G181 D182 S183 G184 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 5tcc G 3.37 BS01 J56 G 1 L40 C41 H56 C57 R152 K195 G196 S198 S214 G215 S216 R217 L25 C26 H41 C42 R135 K178 G179 S181 S197 G198 S199 R200 H56 D104 K195 G196 D197 S198 G199 H41 D87 K178 G179 D180 S181 G182 3.4.21.46 0004252,0005576,0005615,0006508,0006956,0006957,0008236,0009617,0031093,0034774,0070062,1904813 IC50=77nM, Kd=2210nM P00746 27994744 500 ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDDGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA