5t1t A 2.34 BS01 76P A 1 M192 A211 K213 Y262 M265 D272 L318 M30 A49 K51 Y95 M98 D105 L151 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T178 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=58nM -logKd/Ki=7.24, IC50=58nM IC50=58nM Q9NWZ3 28501511 9901 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 5t1t B 2.34 BS01 76P B 1 M192 A211 K213 Y262 M265 D272 L318 M32 A51 K53 Y91 M94 D101 L147 D311 K313 A315 N316 D329 T351 D140 K142 A144 N145 D158 T175 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=58nM IC50=58nM Q9NWZ3 28501511 9901 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 5t1t C 2.34 BS01 76P C 1 M192 A211 K213 Y262 M265 D272 L318 M29 A48 K50 Y95 M98 D105 L151 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=58nM IC50=58nM Q9NWZ3 28501511 9901 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 5t1t D 2.34 BS01 76P D 1 M192 G193 A211 K213 Y262 M265 D272 L318 M29 G30 A48 K50 Y94 M97 D104 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T178 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=58nM IC50=58nM Q9NWZ3 28501511 9901 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA