5os7 A 1.66 BS01 A8Q A 1 N118 F121 L124 L128 Y136 P159 V162 I164 M221 M225 N116 F119 L122 L126 Y134 P157 V160 I162 M219 M223 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 P68400 29732088 404 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 5os7 A 1.66 BS02 A8Q A 2 Q36 D37 Y39 I69 K102 D103 T108 A110 Q34 D35 Y37 I67 K100 D101 T106 A108 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 P68400 29732088 405 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 5os7 A 1.66 BS03 ATP A 1 V53 V66 V116 M163 V51 V64 V114 M161 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 P68400 29732088 406 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 5os7 B 1.66 BS01 A8Q B 1 N118 F121 L124 Y136 P159 V162 I164 M221 M225 N116 F119 L122 Y134 P157 V160 I162 M219 M223 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=3.69, Kd=205uM P68400 29732088 402 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5os7 B 1.66 BS02 ATP B 1 V53 V66 V116 M163 I174 V51 V64 V114 M161 I172 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 P68400 29732088 403 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV