5orh A 1.75 BS01 A4N A 1 Q36 Y39 K102 D103 T108 A110 Q33 Y36 K99 D100 T105 A107 D156 K158 N161 D175 S194 D153 K155 N158 D172 S191 2.7.11.1 0004672,0004674,0005524,0006468 Kd=41uM -logKd/Ki=4.39, Kd=41uM IC50=208000nM P68400 29732088 401 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5orh A 1.75 BS02 A4N A 2 F121 L124 M137 P159 V162 I164 M221 M225 F118 L121 M134 P156 V159 I161 M218 M222 D156 K158 N161 D175 S194 D153 K155 N158 D172 S191 2.7.11.1 0004672,0004674,0005524,0006468 Kd=41uM -logKd/Ki=4.39, Kd=41uM IC50=208000nM P68400 29732088 402 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5orh B 1.75 BS01 A4N B 1 Q36 Y39 K102 D103 T108 Q34 Y37 K100 D101 T106 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 Kd=41uM IC50=208000nM P68400 29732088 401 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5orh B 1.75 BS02 A4N B 2 F121 P159 V162 M221 M225 F119 P157 V160 M219 M223 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 Kd=41uM IC50=208000nM P68400 29732088 402 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV