5olk A 2.45 BS01 DTP A 1 I9 K11 R12 F19 V20 K23 I24 V68 V71 Q72 I5 K7 R8 F15 V16 K19 I20 V64 V67 Q68 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM -logKd/Ki=6.00, Kd=1uM A3XHF9 29388911 1001 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEII 5olk A 2.45 BS02 DTP A 2 R12 A27 N30 A31 A90 Y91 Y94 R98 R102 R8 A23 N26 A27 A86 Y87 Y90 R94 R98 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM -logKd/Ki=6.00, Kd=1uM A3XHF9 29388911 1002 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEII 5olk A 2.45 BS03 MN A 1 E200 E263 E298 H301 E196 E259 E294 H297 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1004 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEII 5olk A 2.45 BS04 MN A 2 E170 E200 H203 E298 E166 E196 H199 E294 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1005 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEII 5olk B 2.45 BS01 DTP B 1 I9 K11 R12 F19 V20 K23 I24 V68 V71 Q72 I3 K5 R6 F13 V14 K17 I18 V62 V65 Q66 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM A3XHF9 29388911 1001 KKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk B 2.45 BS02 DTP B 2 R12 A27 A31 A34 A90 Y91 Y94 R98 R102 R6 A21 A25 A28 A84 Y85 Y88 R92 R96 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM A3XHF9 29388911 1002 KKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk B 2.45 BS03 MN B 1 E170 E200 H203 E298 E164 E194 H197 E292 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1004 KKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk B 2.45 BS04 MN B 2 E200 E263 E298 H301 E194 E257 E292 H295 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1005 KKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk C 2.45 BS01 DTP C 1 I9 K11 R12 F19 V20 K23 I24 V68 V71 Q72 I5 K7 R8 F15 V16 K19 I20 V64 V67 Q68 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM A3XHF9 29388911 1001 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk C 2.45 BS02 DTP C 2 R12 A27 N30 A31 A90 Y91 Y94 R98 R102 R8 A23 N26 A27 A86 Y87 Y90 R94 R98 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM A3XHF9 29388911 1002 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk C 2.45 BS03 MN C 1 E170 E200 H203 E298 E166 E196 H199 E294 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1004 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk C 2.45 BS04 MN C 2 E200 E263 E298 H301 E196 E259 E294 H297 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1005 EIKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk D 2.45 BS01 DTP D 1 I9 K11 R12 F19 V20 K23 I24 V68 V71 Q72 I4 K6 R7 F14 V15 K18 I19 V63 V66 Q67 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM A3XHF9 29388911 1001 IKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk D 2.45 BS02 DTP D 2 R12 A27 N30 A31 Y91 Y94 R98 R102 R7 A22 N25 A26 Y86 Y89 R93 R97 1.17.4.1 0004748,0005524,0009263,0016491,0046872 Kd=1uM A3XHF9 29388911 1002 IKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk D 2.45 BS03 MN D 1 E170 E200 H203 E298 E165 E195 H198 E293 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1004 IKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI 5olk D 2.45 BS04 MN D 2 E200 E263 E298 H301 E195 E258 E293 H296 1.17.4.1 0004748,0005524,0009263,0016491,0046872 A3XHF9 29388911 1005 IKKIIKRDYSTAPFVLEKITNAIANAMAALGHGSEQDAKLISMQVYESLLNNKEQESEYIPTVEQVQDMVEDKLMSSEFHDVAKAYIIYRNKRALERKTNIFEKRINLKPYEYPELNEYVAAIRHSYWIHTEFNFTSDIQDFKTGLSEVERSAIKNTMLAISQIEVAVKTFWGDVHHRLPKPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEFKELKKKPVIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNKHKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPEWFDEEHNNLIKEMCLNSFEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDEALLQETEWFDDEI