5ofu A 2.62 BS01 AMP A 1 I16 S19 Q20 P21 S24 R25 G26 F28 Y113 I10 S13 Q14 P15 S18 R19 G20 F22 Y97 D74 E97 E98 D118 L120 D121 E284 D58 E81 E82 D102 L104 D105 E268 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 -logKd/Ki=4.20, Ki=63.8uM O97193 28882541 401 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu A 2.62 BS02 F6P A 1 D121 G122 Y248 S251 M252 Y268 K278 D105 G106 Y232 S235 M236 Y252 K262 D74 E97 E98 D118 L120 D121 E284 D58 E81 E82 D102 L104 D105 E268 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu B 2.62 BS01 AMP B 1 S19 Q20 P21 S24 R25 G26 F28 Y113 S183 S13 Q14 P15 S18 R19 G20 F22 Y97 S167 D74 E97 E98 D118 L120 D121 E284 D58 E81 E82 D102 L104 D105 E268 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 401 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu B 2.62 BS02 F6P B 1 D121 G122 N218 Y248 G250 S251 M252 Y268 K278 D105 G106 N202 Y232 G234 S235 M236 Y252 K262 D74 E97 E98 D118 L120 D121 E284 D58 E81 E82 D102 L104 D105 E268 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu C 2.62 BS01 AMP C 1 I16 S19 Q20 P21 S24 R25 G26 F28 Y113 S183 I10 S13 Q14 P15 S18 R19 G20 F22 Y93 S163 D74 E97 E98 D118 L120 D121 E284 D55 E78 E79 D98 L100 D101 E264 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 401 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDR 5ofu C 2.62 BS02 F6P C 1 D121 G122 Y248 G250 S251 M252 Y268 K278 D101 G102 Y228 G230 S231 M232 Y248 K258 D74 E97 E98 D118 L120 D121 E284 D55 E78 E79 D98 L100 D101 E264 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDR 5ofu D 2.62 BS01 AMP D 1 I16 S19 Q20 P21 R25 G26 F28 Y113 S183 I10 S13 Q14 P15 R19 G20 F22 Y96 S166 D74 E97 E98 D118 L120 D121 E284 D57 E80 E81 D101 L103 D104 E267 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 401 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu D 2.62 BS02 F6P D 1 D121 G122 Y248 S251 M252 Y268 K278 D104 G105 Y231 S234 M235 Y251 K261 D74 E97 E98 D118 L120 D121 E284 D57 E80 E81 D101 L103 D104 E267 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN