5nbn A 4.0 BS01 ATP A 1 S23 Y24 D159 G161 H162 Q240 K243 E244 G413 T414 S416 Q449 S9 Y10 D145 G147 H148 Q226 K229 E230 G334 T335 S337 Q370 ? 0000785,0000812,0003682,0005515,0005524,0005634,0006281,0006325,0006338,0006351,0006355,0006357,0016514,0031011,0035267,0042393,0043232,0051382 P80428 30177756 502 SAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLN 5nbn B 4.0 BS01 ATP B 1 G22 S23 Y24 G161 H162 Q240 K243 E244 G413 T414 G8 S9 Y10 G147 H148 Q226 K229 E230 G334 T335 ? 0000785,0000812,0003682,0005515,0005524,0005634,0006281,0006325,0006338,0006351,0006355,0006357,0016514,0031011,0035267,0042393,0043232,0051382 P80428 30177756 502 SAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLN 5nbn C 4.0 BS01 ATP C 1 G13 S14 G15 M16 K18 G156 D157 V159 K213 E214 G302 F306 K336 G9 S10 G11 M12 K14 G141 D142 V144 K198 E199 G287 F291 K321 3.6.4.- 0000011,0000142,0000785,0000812,0005200,0005515,0005524,0005634,0005737,0005856,0005884,0006281,0006338,0006351,0006355,0006897,0009306,0016787,0016887,0030010,0030476,0030479,0031011,0032432,0035267,0042802,0043232,1902404 P60010 30177756 502 VAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKC 5nbn C 4.0 BS02 LAR C 1 M16 P32 Q59 Y69 D157 G182 R183 T186 E207 R210 M12 P28 Q44 Y54 D142 G167 R168 T171 E192 R195 3.6.4.- 0000011,0000142,0000785,0000812,0005200,0005515,0005524,0005634,0005737,0005856,0005884,0006281,0006338,0006351,0006355,0006897,0009306,0016787,0016887,0030010,0030476,0030479,0031011,0032432,0035267,0042802,0043232,1902404 IC50=70nM P60010 30177756 503 VAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKC 5nbn D 4.0 BS01 ATP D 1 G13 S14 K18 G156 D157 V159 K213 E214 G301 G302 M305 F306 K336 G9 S10 K14 G141 D142 V144 K198 E199 G286 G287 M290 F291 K321 3.6.4.- 0000011,0000142,0000785,0000812,0005200,0005515,0005524,0005634,0005737,0005856,0005884,0006281,0006338,0006351,0006355,0006897,0009306,0016787,0016887,0030010,0030476,0030479,0031011,0032432,0035267,0042802,0043232,1902404 P60010 30177756 502 VAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKC 5nbn D 4.0 BS02 LAR D 1 M16 P32 Q59 Y69 D157 G182 T186 R206 E207 R210 M12 P28 Q44 Y54 D142 G167 T171 R191 E192 R195 3.6.4.- 0000011,0000142,0000785,0000812,0005200,0005515,0005524,0005634,0005737,0005856,0005884,0006281,0006338,0006351,0006355,0006897,0009306,0016787,0016887,0030010,0030476,0030479,0031011,0032432,0035267,0042802,0043232,1902404 IC50=70nM P60010 30177756 503 VAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKC