5mf6 A 1.87 BS01 AR6 A 1 G52 A53 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258 G43 A44 G45 T48 D54 F55 R56 Q104 H124 G198 T199 S200 I203 N224 L225 Q226 Y241 V242 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 27990725 401 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 5mf6 A 1.87 BS02 ZN A 1 C141 C144 C166 C177 C132 C135 C157 C161 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 27990725 402 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 5mf6 A 1.87 BS03 7M2 A 1 I61 P62 F64 F86 I52 P53 F55 F77 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Kd=38uM -logKd/Ki=4.36, Kd=44uM EC50=38000nM Q8N6T7 27990725 410 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 5mf6 B 1.87 BS01 AR6 B 1 G52 A53 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258 G38 A39 G40 T43 D49 F50 R51 Q99 H119 G193 T194 S195 I198 N219 L220 Q221 Y236 V237 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 27990725 401 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPK 5mf6 B 1.87 BS02 ZN B 1 C141 C144 C166 C127 C130 C152 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 27990725 402 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPK 5mf6 B 1.87 BS03 7M2 B 1 P62 F82 F86 M157 P48 F68 F72 M143 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Kd=38uM EC50=38000nM Q8N6T7 27990725 408 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPK