5mat A 2.069 BS01 ZN A 1 C195 C200 C221 C224 C139 C144 C165 C168 P94 D95 F96 R97 N168 D170 H187 P40 D41 F42 R43 N112 D114 H131 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 28135086 401 MERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS 5mat A 2.069 BS02 7KJ A 1 I93 P94 F96 F119 A135 L138 Y139 F143 I169 F190 F235 I39 P40 F42 F63 A79 L82 Y83 F87 I113 F134 F179 P94 D95 F96 R97 N168 D170 H187 P40 D41 F42 R43 N112 D114 H131 2.3.1.-,2.3.1.286 0017136,0051287,0070403 ic50=0.58uM -logKd/Ki=6.24, IC50=0.58uM IC50=580nM Q8IXJ6 28135086 402 MERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS 5mat C 2.069 BS01 ZN C 1 C195 C200 C221 C137 C142 C163 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 28135086 401 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS