5mar A 1.89 BS01 ZN A 1 C195 C200 C221 C224 C142 C147 C168 C171 P94 D95 F96 R97 N168 D170 H187 P41 D42 F43 R44 N115 D117 H134 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 28240897 401 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ 5mar A 1.89 BS02 AR6 A 1 G84 A85 G86 T89 D95 F96 R97 Y104 Q167 H187 F235 G261 T262 S263 V266 N286 K287 E288 E323 C324 G31 A32 G33 T36 D42 F43 R44 Y51 Q114 H134 F182 G208 T209 S210 V213 N233 K234 E235 E270 C271 P94 D95 F96 R97 N168 D170 H187 P41 D42 F43 R44 N115 D117 H134 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 28240897 402 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ 5mar A 1.89 BS03 7KE A 1 F119 L134 L138 I169 I232 V233 F66 L81 L85 I116 I179 V180 P94 D95 F96 R97 N168 D170 H187 P41 D42 F43 R44 N115 D117 H134 2.3.1.-,2.3.1.286 0017136,0051287,0070403 ic50=41.2uM -logKd/Ki=4.39, IC50=41.2uM IC50=41200nM Q8IXJ6 28240897 403 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ 5mar B 1.89 BS01 ZN B 1 C195 C200 C221 C224 C142 C147 C168 C171 P94 D95 F96 R97 N168 D170 H187 P41 D42 F43 R44 N115 D117 H134 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 28240897 401 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ 5mar B 1.89 BS02 AR6 B 1 G84 A85 G86 T89 D95 F96 R97 Y104 Q167 H187 F235 G261 T262 S263 N286 K287 E288 E323 C324 G31 A32 G33 T36 D42 F43 R44 Y51 Q114 H134 F182 G208 T209 S210 N233 K234 E235 E270 C271 P94 D95 F96 R97 N168 D170 H187 P41 D42 F43 R44 N115 D117 H134 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 28240897 402 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ 5mar B 1.89 BS03 7KE B 1 F96 L103 F119 L134 L138 I169 V233 F43 L50 F66 L81 L85 I116 V180 P94 D95 F96 R97 N168 D170 H187 P41 D42 F43 R44 N115 D117 H134 2.3.1.-,2.3.1.286 0017136,0051287,0070403 ic50=41.2uM IC50=41200nM Q8IXJ6 28240897 403 HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ