5m4q A 1.73 BS01 MN A 1 D287 H370 T410 E412 E452 D282 H365 T405 E407 E447 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 P12955 28677335 499 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPF 5m4q A 1.73 BS02 MN A 2 Y241 D276 D287 E452 Y236 D271 D282 E447 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 P12955 28677335 500 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPF 5m4q A 1.73 BS03 OH A 1 E412 E452 E407 E447 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 P12955 28677335 501 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPF 5m4q A 1.73 BS04 PRO A 1 H255 H366 R398 E412 H250 H361 R393 E407 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 Ki=0.31mM -logKd/Ki=3.51, Ki=0.31mM P12955 28677335 504 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPF 5m4q B 1.73 BS01 MN B 1 D287 H370 T410 E412 E452 D282 H365 T405 E407 E447 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 P12955 28677335 499 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCD 5m4q B 1.73 BS02 MN B 2 Y241 D276 D287 E452 Y236 D271 D282 E447 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 P12955 28677335 500 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCD 5m4q B 1.73 BS03 OH B 1 E412 E452 E407 E447 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 P12955 28677335 501 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCD 5m4q B 1.73 BS04 PRO B 1 H255 H366 R398 E412 R450 H250 H361 R393 E407 R445 D60 H255 D276 D287 H366 H370 H377 E412 Y416 R450 E452 D55 H250 D271 D282 H361 H365 H372 E407 Y411 R445 E447 3.4.13.9 0004181,0005515,0006508,0006520,0008233,0008237,0016805,0030145,0030574,0043069,0046872,0070006,0070062,0102009 Ki=0.31mM -logKd/Ki=3.51, Ki=0.31mM P12955 28677335 504 GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCD