5lxc A 2.15 BS01 7AA A 1 G156 K157 F160 V163 A176 K178 F228 L231 E279 L282 I294 G77 K78 F81 V84 A97 K99 F149 L152 E200 L203 I215 D275 K277 N280 D295 S312 D196 K198 N201 D216 S233 2.7.12.1 0004672,0004712,0005524,0006468 ic50=10.8nM -logKd/Ki=7.97, IC50=10.8nM Q92630 27766861 501 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 5lxc B 2.15 BS01 7AA B 1 K157 F160 A176 K178 F228 L231 E279 L282 I294 D295 K78 F81 A97 K99 F149 L152 E200 L203 I215 D216 D275 K277 N280 D295 S312 D196 K198 N201 D216 S233 2.7.12.1 0004672,0004712,0005524,0006468 ic50=10.8nM Q92630 27766861 501 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR