5lmk A 2.4 BS01 6ZK A 1 I10 E12 A31 F80 F82 L83 H84 Q85 Q131 L134 I11 E13 A32 F79 F81 L82 H83 Q84 Q130 L133 D127 K129 Q131 N132 D145 T158 T165 D126 K128 Q130 N131 D144 T157 T164 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 -logKd/Ki=7.43, IC50=0.037uM IC50=37nM P24941 28039837 301 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 5lmk B 2.4 BS01 MG B 1 Q203 I206 Q29 I32 ? 0016538,0044772 P20248 28039837 502 VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 5lmk C 2.4 BS01 6ZK C 1 I10 E12 A31 F80 F82 L83 H84 Q85 Q131 L134 I11 E13 A32 F81 F83 L84 H85 Q86 Q132 L135 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 IC50=37nM P24941 28039837 301 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL