5ll5 A 1.42 BS01 ZN A 1 H91 H93 H117 H89 H91 H115 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 O43570 301 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 A 1.42 BS02 6YH A 1 H91 H93 H117 S133 L197 T198 T199 W208 H89 H91 H115 S131 L195 T196 T197 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 -logKd/Ki=6.04, Kd=909nM Kd=320nM, kon=280000M-1-s-1, koff=0.051s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 B 1.42 BS01 ZN B 1 H91 H93 H117 H89 H91 H115 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 O43570 301 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 B 1.42 BS02 6YH B 1 H91 H93 H117 S133 L197 T198 T199 H89 H91 H115 S131 L195 T196 T197 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=320nM, kon=280000M-1-s-1, koff=0.051s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 C 1.42 BS01 ZN C 1 H91 H93 H117 H89 H91 H115 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 O43570 301 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 C 1.42 BS02 6YH C 1 H91 H117 V119 S133 L197 T198 T199 P201 W208 H89 H115 V117 S131 L195 T196 T197 P199 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=320nM, kon=280000M-1-s-1, koff=0.051s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 D 1.42 BS01 ZN D 1 H91 H93 H117 H89 H91 H115 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 O43570 301 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll5 D 1.42 BS02 6YH D 1 H91 H93 H117 V119 A129 S130 S133 L197 T198 T199 W208 H89 H91 H115 V117 A127 S128 S131 L195 T196 T197 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=320nM, kon=280000M-1-s-1, koff=0.051s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ