5lih A 3.25 BS01 peptide F 0 S264 M341 Q345 D382 M399 F413 C414 G415 T416 P417 E445 G449 S17 M87 Q91 D128 M145 F159 C160 G161 T162 P163 E191 G195 D378 K380 N383 D396 T416 D124 K126 N129 D142 T162 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 2 ~ 14 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS02 ADP A 1 G263 Y265 A266 V268 A281 K283 I332 E333 V335 D339 D382 L385 D396 F552 G16 Y18 A19 V21 A34 K36 I78 E79 V81 D85 D128 L131 D142 F290 D378 K380 N383 D396 T416 D124 K126 N129 D142 T162 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 601 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS03 AF3 A 1 R377 Y419 V434 R123 Y165 V180 D378 K380 N383 D396 T416 D124 K126 N129 D142 T162 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 602 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS04 MN A 1 N383 D396 N129 D142 D378 K380 N383 D396 T416 D124 K126 N129 D142 T162 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 603 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS05 MN A 2 D396 G398 D142 G144 D378 K380 N383 D396 T416 D124 K126 N129 D142 T162 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 604 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS06 AF3 A 2 S264 K380 D396 S17 K126 D142 D378 K380 N383 D396 T416 D124 K126 N129 D142 T162 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 605 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS01 peptide G 0 S264 Y265 D339 M341 M344 Q345 M399 F413 C414 G415 P417 E445 G449 R450 S16 Y17 D82 M84 M87 Q88 M142 F156 C157 G158 P160 E188 G192 R193 D378 K380 N383 D396 T416 D121 K123 N126 D139 T159 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 5 ~ 14 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS02 ADP B 1 G263 V268 A281 K283 I332 E333 V335 D339 D382 L385 D396 F552 G15 V20 A33 K35 I75 E76 V78 D82 D125 L128 D139 F284 D378 K380 N383 D396 T416 D121 K123 N126 D139 T159 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 601 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS03 AF3 B 1 R377 Y419 V434 R120 Y162 V177 D378 K380 N383 D396 T416 D121 K123 N126 D139 T159 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 602 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS04 MN B 1 N383 D396 N126 D139 D378 K380 N383 D396 T416 D121 K123 N126 D139 T159 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 603 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS05 AF3 B 2 G263 S264 D396 G15 S16 D139 D378 K380 N383 D396 T416 D121 K123 N126 D139 T159 2.7.11.13 0004672,0004674,0005524,0006468,0007163 P41743 27554858 605 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL