5lhg A 3.34 BS01 FAD A 1 G285 G287 S289 E308 A309 R310 G315 R316 G330 A331 M332 V333 V590 L625 P626 W751 W756 S760 Y761 G800 E801 T810 V811 A814 G115 G117 S119 E138 A139 R140 G145 R146 G160 A161 M162 V163 V420 L455 P456 W581 W586 S590 Y591 G630 E631 T640 V641 A644 T335 T165 1.14.99.66 0000122,0000781,0000785,0002039,0002052,0003682,0003713,0005515,0005634,0005654,0005667,0005694,0006325,0006338,0006355,0006357,0006482,0010569,0010718,0010976,0014070,0016491,0019899,0021987,0030374,0031398,0032091,0032451,0032452,0032453,0032454,0032880,0032991,0034644,0036211,0042162,0042551,0042802,0043392,0043426,0043433,0043518,0045793,0045892,0045944,0046098,0050660,0050681,0055001,0060765,0060992,0061629,0061752,0071320,0071480,0090308,0120162,0140297,0140682,0140861,1902166,1990391,1990841,2000179,2000648 O60341 28186757 901 PSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTL 5lhg A 3.34 BS02 6X3 A 1 V333 Q358 C360 E379 N535 F538 L677 L693 W695 T810 V163 Q188 C190 E209 N365 F368 L507 L523 W525 T640 T335 T165 1.14.99.66 0000122,0000781,0000785,0002039,0002052,0003682,0003713,0005515,0005634,0005654,0005667,0005694,0006325,0006338,0006355,0006357,0006482,0010569,0010718,0010976,0014070,0016491,0019899,0021987,0030374,0031398,0032091,0032451,0032452,0032453,0032454,0032880,0032991,0034644,0036211,0042162,0042551,0042802,0043392,0043426,0043433,0043518,0045793,0045892,0045944,0046098,0050660,0050681,0055001,0060765,0060992,0061629,0061752,0071320,0071480,0090308,0120162,0140297,0140682,0140861,1902166,1990391,1990841,2000179,2000648 -logKd/Ki=5.60, IC50=2.5uM IC50=2500nM O60341 28186757 906 PSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTL 5lhg A 3.34 BS03 6X3 A 2 A539 D555 H564 A809 A369 D385 H394 A639 T335 T165 1.14.99.66 0000122,0000781,0000785,0002039,0002052,0003682,0003713,0005515,0005634,0005654,0005667,0005694,0006325,0006338,0006355,0006357,0006482,0010569,0010718,0010976,0014070,0016491,0019899,0021987,0030374,0031398,0032091,0032451,0032452,0032453,0032454,0032880,0032991,0034644,0036211,0042162,0042551,0042802,0043392,0043426,0043433,0043518,0045793,0045892,0045944,0046098,0050660,0050681,0055001,0060765,0060992,0061629,0061752,0071320,0071480,0090308,0120162,0140297,0140682,0140861,1902166,1990391,1990841,2000179,2000648 -logKd/Ki=5.60, IC50=2.5uM IC50=2500nM O60341 28186757 907 PSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTL