5lf3 b 2.1 BS01 BO2 b 1 T1 T20 T21 G47 A49 M95 T1 T20 T21 G47 A49 M95 3.4.25.1 0004298,0005839,0051603 P28072 27493187 305 TTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLP 5lf3 H 2.1 BS01 MG H 1 I163 D166 S169 I163 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 Q99436 27493187 302 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLE 5lf3 H 2.1 BS02 BO2 H 1 T1 A20 T21 E22 A46 G47 A49 T1 A20 T21 E22 A46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 IC50=120nM Q99436 27493187 306 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLE 5lf3 H 2.1 BS03 BO2 N 1 Y114 S118 Y114 S118 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 IC50=120nM Q99436 27493187 304 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLE 5lf3 I 2.1 BS01 MG I 1 V174 D177 S180 V174 D177 S180 3.4.25.1 0000502,0005515,0005634,0005654,0005737,0005829,0005839,0019774,0043161,0051603,0070062 P49720 27493187 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD 5lf3 K 2.1 BS01 MG K 1 T164 D167 A168 S170 T164 D167 A168 S170 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074 27493187 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYS 5lf3 K 2.1 BS02 BO2 K 1 T1 A20 T21 G47 A49 T1 A20 T21 G47 A49 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 IC50=11nM, Ki=9.8nM P28074 27493187 305 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYS 5lf3 N 2.1 BS01 BO2 N 1 T1 T20 T21 G47 A49 M95 T1 T20 T21 G47 A49 M95 D17 R19 K33 G47 S130 D167 S170 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28072 27493187 304 TTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATL 5lf3 V 2.1 BS01 MG L 1 I163 D166 S169 I163 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 Q99436 27493187 303 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLE 5lf3 V 2.1 BS02 BO2 V 1 T1 A20 T21 E22 A46 G47 A49 T1 A20 T21 E22 A46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 IC50=120nM Q99436 27493187 303 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLE 5lf3 V 2.1 BS03 BO2 b 1 Y114 S118 Y114 S118 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 IC50=120nM Q99436 27493187 305 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLE 5lf3 W 2.1 BS01 MG W 1 V174 D177 S180 V174 D177 S180 3.4.25.1 0000502,0005515,0005634,0005654,0005737,0005829,0005839,0019774,0043161,0051603,0070062 P49720 27493187 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD 5lf3 Y 2.1 BS01 MG I 2 T164 D167 A168 S170 T164 D167 A168 S170 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074 27493187 305 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSG 5lf3 Y 2.1 BS02 BO2 Y 1 T1 A20 T21 G47 A49 T1 A20 T21 G47 A49 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 IC50=11nM, Ki=9.8nM P28074 27493187 305 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSG