5l7f A 1.8 BS01 ZN A 1 H218 H222 H228 H113 H117 H123 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 301 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS02 ZN A 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 302 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS03 CA A 1 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 303 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS04 CA A 2 D158 G190 G192 D194 D53 G85 G87 D89 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 304 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS05 CA A 3 D124 E199 E201 D19 E94 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 305 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS06 R47 A 1 G179 I180 L181 A182 T215 H218 E219 H222 H228 K233 A234 V235 F237 P238 T239 Y240 A241 V243 G74 I75 L76 A77 T110 H113 E114 H117 H123 K128 A129 V130 F132 P133 T134 Y135 A136 V138 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 Ki=0.260000nM P39900 27564088 309 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS07 6PJ B 1 K233 Y242 V243 R249 S251 A252 K128 Y137 V138 R144 S146 A147 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=9.05, Ki=0.90nM P39900 27564088 301 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.8 BS08 R47 B 1 S230 P232 S125 P127 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 Ki=0.260000nM P39900 27564088 307 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS01 R47 A 1 S230 P232 S125 P127 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 Ki=0.260000nM P39900 27564088 309 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS02 6PJ A 1 P232 K233 T247 F248 R249 S251 A252 P127 K128 T142 F143 R144 S146 A147 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 310 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS03 ZN B 1 H218 H222 H228 H113 H117 H123 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 302 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS04 ZN B 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 303 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS05 CA B 1 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 304 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS06 CA B 2 D158 G190 G192 D194 D53 G85 G87 D89 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 305 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS07 CA B 3 D124 E199 E201 D19 E94 E96 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27564088 306 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.8 BS08 R47 B 1 G179 I180 L181 A182 T215 H218 E219 H222 H228 K233 A234 V235 F237 T239 Y240 A241 V243 G74 I75 L76 A77 T110 H113 E114 H117 H123 K128 A129 V130 F132 T134 Y135 A136 V138 H218 E219 H222 H228 H113 E114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 Ki=0.260000nM P39900 27564088 307 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG