5l26 A 3.4 BS01 6ZL A 1 L42 V127 F131 L44 V129 F133 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 502 PRMVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAEVLAENEDEKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGAS 5l26 A 3.4 BS02 6ZL A 2 Y117 I118 Y119 I120 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 503 PRMVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAEVLAENEDEKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGAS 5l26 A 3.4 BS03 6ZL A 3 T62 I63 T64 I65 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 504 PRMVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAEVLAENEDEKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGAS 5l26 A 3.4 BS04 URI A 1 Q154 E332 F333 F366 S371 V374 Q156 E329 F330 F363 S368 V371 ? 0005337,0005886,0015293,0016020,1901642 -logKd/Ki=5.35, Kd=4.5uM G4CRQ5 28424521 505 PRMVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAEVLAENEDEKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGAS 5l26 B 3.4 BS01 6ZL B 1 G130 F131 G130 F131 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 502 MVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGWFGHGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGASVL 5l26 B 3.4 BS02 6ZL B 2 N65 Y69 N65 Y69 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 503 MVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGWFGHGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGASVL 5l26 B 3.4 BS03 URI B 1 Q154 E332 F333 F366 S371 Q154 E323 F324 F357 S362 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 504 MVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGGWFGHGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTGLSGASVL 5l26 C 3.4 BS01 URI C 1 Q154 E332 F333 F366 S371 V374 Q155 E321 F322 F355 S360 V363 ? 0005337,0005886,0015293,0016020,1901642 G4CRQ5 28424521 503 RMVVLHSLLGMAVLIAIAVLLSTDRKAINIRTVAGAFLIQVALGALVLYVPQGRDMLGEASKTISNVIAYGNNGVDFLFGGLVSEKMFEVFGGGGFVFALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKMLGTSKAESMSAAANIFVGQTEAPLVVRPYIRRMTESELFAVMSGGLASVAGSVLAGYVQMGVPLPYLIAASFMAAPGGLLFAKLLVPETERTQNDAEVLKPTNVIDAAASGAVTGAQIAIAVGASLLAFVALIAMINGIIGGVGDLTLQAILGWLFSPLAWVIGVPWSEAGIAGSLIGQKVVINEFVAYSEFVKYLKPEAAVQLSDTTKAIISFALCGFANLGSIAVLVGGLSIMAPKRRKDVARLGIKAVVAGSLSNLMSAVIAGLFTG