5l13 A 2.4 BS01 6ZE A 1 F170 M174 W177 F296 C301 C302 C303 D457 F459 F164 M168 W171 F290 C295 C296 C297 D451 F453 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM -logKd/Ki=6.96, IC50=0.11uM Ki=19nM, IC50=110nM P05091 28219011 606 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 B 2.4 BS01 6ZE B 1 F170 W177 F296 C301 C302 C303 D457 F459 F164 W171 F290 C295 C296 C297 D451 F453 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 605 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 C 2.4 BS01 6ZE C 1 F170 W177 F296 C301 C302 C303 D457 F459 F164 W171 F290 C295 C296 C297 D451 F453 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 603 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 D 2.4 BS01 6ZE D 1 V120 F170 M174 W177 F296 C301 C302 C303 D457 F459 V114 F164 M168 W171 F290 C295 C296 C297 D451 F453 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 607 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 E 2.4 BS01 6ZE E 1 F170 W177 F296 C301 C302 C303 D457 F459 F165 W172 F291 C296 C297 C298 D452 F454 N169 K192 E268 C302 E399 E476 N164 K187 E263 C297 E394 E471 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 607 QAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 F 2.4 BS01 6ZE F 1 F170 M174 W177 F296 C301 C302 C303 D457 F459 F164 M168 W171 F290 C295 C296 C297 D451 F453 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 605 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 G 2.4 BS01 6ZE G 1 F170 W177 F296 C301 C302 C303 D457 F459 F465 F164 W171 F290 C295 C296 C297 D451 F453 F459 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 608 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 5l13 H 2.4 BS01 6ZE H 1 F170 M174 W177 F296 C301 C302 C303 D457 F459 F164 M168 W171 F290 C295 C296 C297 D451 F453 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=19nM Ki=19nM, IC50=110nM P05091 28219011 603 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS