5kxi A 3.941 BS01 NCT A 1 Y100 W156 T157 Y204 Y93 W149 T150 Y197 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 -logKd/Ki=7.74, Ki=18.2nM Ki=2nM, IC50=430nM, EC50=2400nM P43681 27698419 402 AHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 5kxi B 3.941 BS01 NCT A 1 W57 L121 W57 L121 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 -logKd/Ki=7.74, Ki=18.2nM IC50=3.8nM, Ki=12.0nM, EC50=132000nM P17787 27698419 402 TDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPL 5kxi D 3.941 BS01 NCT D 1 Y100 W156 T157 Y204 Y93 W149 T150 Y197 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 Ki=2nM, IC50=430nM, EC50=2400nM P43681 27698419 402 AHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 5kxi E 3.941 BS01 NCT D 1 W57 L121 W57 L121 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 IC50=3.8nM, Ki=12.0nM, EC50=132000nM P17787 27698419 402 TDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPL