5kcz A 1.14 BS01 ZN A 1 C46 H67 C174 C46 H67 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28025168 375 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz A 1.14 BS02 ZN A 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28025168 376 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz A 1.14 BS03 NAJ A 1 C46 R47 T48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 R369 C46 R47 T48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Kd=15uM P00327 28025168 377 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz A 1.14 BS04 ETF A 1 T48 H67 F93 C174 T48 H67 F93 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=98uM P00327 28025168 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz B 1.14 BS01 ZN B 1 C46 H67 C174 C46 H67 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28025168 375 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz B 1.14 BS02 ZN B 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 28025168 376 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz B 1.14 BS03 NAJ B 1 C46 R47 T48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 C46 R47 T48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Kd=15uM P00327 28025168 377 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 5kcz B 1.14 BS04 ETF B 1 T48 H67 F93 C174 T48 H67 F93 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=98uM P00327 28025168 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRTDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF