5k09 A 2.7 BS01 6PQ A 1 M89 E90 I91 S119 H142 W143 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 -logKd/Ki=6.00, IC50=1.0uM P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSD 5k09 B 2.7 BS01 6PQ B 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 C 2.7 BS01 6PQ C 1 E90 I91 S119 H142 W143 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 D 2.7 BS01 6PQ D 1 M89 E90 I91 S119 H142 W143 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 E 2.7 BS01 6PQ E 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 F 2.7 BS01 6PQ F 1 E90 I91 A118 S119 H142 W143 E89 I90 A117 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 G 2.7 BS01 6PQ G 1 M89 E90 I91 S119 H142 W143 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSD 5k09 H 2.7 BS01 6PQ H 1 M89 E90 I91 S119 H142 W143 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 I 2.7 BS01 6PQ I 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 J 2.7 BS01 6PQ J 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 K 2.7 BS01 6PQ K 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 L 2.7 BS01 6PQ L 1 M89 E90 I91 S119 H142 W143 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 M 2.7 BS01 6PQ M 1 G66 E90 I91 S119 H142 W143 G65 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 N 2.7 BS01 6PQ N 1 E90 I91 S119 H142 W143 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 O 2.7 BS01 6PQ O 1 G66 M89 E90 I91 A118 S119 H142 W143 G65 M88 E89 I90 A117 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 P 2.7 BS01 6PQ P 1 E90 I91 A118 S119 H142 W143 E89 I90 A117 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 Q 2.7 BS01 6PQ Q 1 M89 E90 I91 S119 H142 W143 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5k09 R 2.7 BS01 6PQ R 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSD 5k09 S 2.7 BS01 6PQ S 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 T 2.7 BS01 6PQ T 1 G66 M89 E90 I91 S119 H142 W143 G65 M88 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 U 2.7 BS01 6PQ U 1 G66 E90 I91 S119 H142 W143 G65 E89 I90 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 V 2.7 BS01 6PQ V 1 G66 M89 E90 I91 A118 S119 H142 W143 G65 M88 E89 I90 A117 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 W 2.7 BS01 6PQ W 1 M89 E90 I91 A118 S119 H142 W143 M88 E89 I90 A117 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5k09 X 2.7 BS01 6PQ X 1 E90 I91 A118 S119 H142 W143 E89 I90 A117 S118 H141 W142 D141 K144 D169 N170 E199 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 27685665 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS