5jyo B 2.098 BS01 63J C 1 K320 L321 F322 L323 Y394 K100 L101 F102 L103 Y174 S286 K289 Y414 Y466 V484 S69 K72 Y194 Y246 V264 3.5.1.2 0004359,0006541 IC50=5.0nM, Kd=92nM O94925 27462863 601 GSMIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYD 5jyo C 2.098 BS01 63J C 1 K320 L321 F322 L323 Y394 K100 L101 F102 L103 Y174 S286 K289 Y414 Y466 V484 S69 K72 Y194 Y246 V264 3.5.1.2 0004359,0006541 IC50=5.0nM, Kd=92nM O94925 27462863 601 GSMIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYD 5jyo D 2.098 BS01 63J D 1 K320 L321 F322 L323 E325 Y394 K100 L101 F102 L103 E105 Y174 S286 K289 Y414 Y466 V484 S69 K72 Y194 Y246 V264 3.5.1.2 0004359,0006541 -logKd/Ki=8.52, IC50=0.003uM IC50=5.0nM, Kd=92nM O94925 27462863 601 GSMIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYD 5jyo E 2.098 BS01 63J D 1 K320 L321 F322 L323 Y394 K100 L101 F102 L103 Y174 S286 K289 Y414 Y466 V484 S69 K72 Y194 Y246 V264 3.5.1.2 0004359,0006541 IC50=5.0nM, Kd=92nM O94925 27462863 601 GSMIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYD 5jyo F 2.098 BS01 63J F 1 K320 L321 F322 L323 N324 Y394 K100 L101 F102 L103 N104 Y174 S286 K289 Y414 Y466 V484 S69 K72 Y194 Y246 V264 3.5.1.2 0004359,0006541 IC50=5.0nM, Kd=92nM O94925 27462863 601 GSMIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYD