5jl9 A 3.1 BS01 HEM A 1 R115 I132 W141 R145 A306 V373 R375 F430 R435 G436 C437 M447 R71 I88 W97 R101 A262 V329 R331 F386 R391 G392 C393 M403 T310 F430 C437 T266 F386 C393 1.14.14.14 0002677,0004497,0005506,0005783,0005789,0006629,0006694,0006703,0006710,0006949,0008209,0008395,0008585,0009055,0010760,0016020,0016125,0016705,0016712,0019825,0020037,0030540,0030879,0032355,0046872,0060065,0060736,0061370,0070330,2000866 P11511 29476820 600 SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRN 5jl9 A 3.1 BS02 ASD A 1 R115 I133 W224 D309 T310 L372 M374 L477 R71 I89 W180 D265 T266 L328 M330 L433 T310 F430 C437 T266 F386 C393 1.14.14.14 0002677,0004497,0005506,0005783,0005789,0006629,0006694,0006703,0006710,0006949,0008209,0008395,0008585,0009055,0010760,0016020,0016125,0016705,0016712,0019825,0020037,0030540,0030879,0032355,0046872,0060065,0060736,0061370,0070330,2000866 IC50=300nM, Ki=20nM P11511 29476820 601 SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRN