5j1v A 2.52 BS01 6FD A 1 L167 V175 A189 K191 F241 L244 L295 L22 V30 A44 K46 F96 L99 L150 D288 K290 N293 D325 T342 D143 K145 N148 D180 T197 2.7.12.1 0004672,0005524,0006468 -logKd/Ki=7.39, IC50=0.041uM IC50=41nM P49759 27128181 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKS 5j1v B 2.52 BS01 6FD B 1 L167 A189 K191 F241 L244 L295 V324 L22 A44 K46 F96 L99 L150 V179 D288 K290 N293 D325 T342 D143 K145 N148 D180 T197 2.7.12.1 0004672,0005524,0006468 IC50=41nM P49759 27128181 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 5j1v C 2.52 BS01 6FD C 1 L167 V175 A189 K191 F241 E242 L244 L295 L22 V30 A44 K46 F96 E97 L99 L150 D288 K290 N293 D325 D143 K145 N148 D180 2.7.12.1 0004672,0005524,0006468 IC50=41nM P49759 27128181 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKS